From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development

被引：130
|
作者：
O'Garra, Anne [1 ]
Murphy, Kenneth M. [2 ,3 ]
机构：
[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England
[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Howard Hughes Med Inst, Ctr Immunol, St Louis, MO 63110 USA
来源：
NATURE IMMUNOLOGY | 2009年 / 10卷 / 09期
基金：
英国医学研究理事会;
关键词：
INHIBITS CYTOKINE PRODUCTION; INTERFERON-GAMMA PRODUCTION; CD4+ T-CELLS; TH1; CELLS; PHENOTYPE DEVELOPMENT; DENDRITIC CELLS; INTERLEUKIN-10; MACROPHAGES; CLONES; GENE;
D O I：
10.1038/ni0909-929
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.
引用
收藏
页码：929 / 932
页数：4
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