Apatinib for molecular targeted therapy in tumor

被引：195

作者：

Zhang, Haijun ^{[1
]}

机构：

[1] Southeast Univ, Dept Oncol, Zhongda Hosp, Sch Med, Nanjing 210009, Jiangsu, Peoples R China

来源：

DRUG DESIGN DEVELOPMENT AND THERAPY | 2015年 / 9卷

基金：

中国国家自然科学基金;

关键词：

apatinib; angiogenesis; vascular endothelial growth factor receptor-2; molecular targeted therapy; tumor; GROWTH-FACTOR RECEPTOR-2; MULTICENTER PHASE-II; MULTIDRUG-RESISTANCE; BREAST-CANCER; GASTRIC-CANCER; IN-VITRO; INHIBITOR; YN968D1; PHARMACOKINETICS; EFFICACY;

D O I：

10.2147/DDDT.S97235

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As tumor angiogenesis is one of the hallmarks of cancer, the inhibition of vascular endothelial growth factor signaling has become an attractive anticancer approach. Apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor-2, has demonstrated encouraging anticancer activity across a broad range of malignancies, including gastric cancer, non-small-cell lung cancer, breast cancer, and hepatocellular carcinoma. In this up-to-date review, focus is not only on the structure, mechanisms, and pharmacokinetics of apatinib, but also on summarizing clinical trials and making recommendations of apatinib for patients with advanced solid tumors.

引用

页码：6075 / 6081

页数：7

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