Design, Degradation Mechanism and Long-Term Cytotoxicity of Poly(l-lactide) and Poly(Lactide-co-E-Caprolactone) Terpolymer Film and Air-Spun Nanofiber Scaffold

被引：25

作者：

Sabbatier, Gad ^{[1
,2
,3
]}

Larranaga, Aitor ^{[4
]}

Guay-Begin, Andree-Anne ^{[2
]}

Fernandez, Jorge ^{[4
]}

Dieval, Florence ^{[3
]}

Durand, Bernard ^{[3
]}

Sarasua, Jose-Ramon ^{[4
]}

Laroche, Gaetan ^{[1
,2
]}

机构：

[1] Univ Laval, Lab Ingn Surface, Ctr Rech Mat Avances, Dept Genie Mines Met & Mat, Quebec City, PQ G1V 0A6, Canada

[2] Hop St Francois Assise, CHU Quebec, Ctr Rech, Axe Med Regeneratrice, Quebec City, PQ G1L 3L5, Canada

[3] Univ Haute Alsace, Lab Phys & Mecan Text, Ecole Natl Super Ingn Sud Alsace, F-68093 Mulhouse, France

[4] Univ Basque Country UPV EHU, Sch Engn, Dept Mining Met Engn & Mat Sci, Bilbao 48013, Spain

来源：

MACROMOLECULAR BIOSCIENCE | 2015年 / 15卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

biodegradable; biomaterials; nanofibers; Poly(lactide-co-E-caprolactone); polylactides; ELECTROSPUN NANOFIBERS; HYDROLYTIC DEGRADATION; BIODEGRADABLE POLYMERS; SYNTHETIC-POLYMERS; FIBER DIAMETER; STEM-CELLS; BIOCOMPATIBILITY; PROLIFERATION; ADHESION; CRYSTALLIZATION;

D O I：

10.1002/mabi.201500130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Degradable nanofiber scaffold is known to provide a suitable, versatile and temporary structure for tissue regeneration. However, synthetic nanofiber scaffold must be properly designed to display appropriate tissue response during the degradation process. In this context, this publication focuses on the design of a finely-tuned poly(lactide-co-E-caprolactone) terpolymer (PLCL) that may be appropriate for vascular biomaterials applications and its comparison with well-known semi-crystalline poly(l-lactide) (PLLA). The degradation mechanism of polymer film and nanofiber scaffold and endothelial cells behavior cultured with degradation products is elucidated. The results highlights benefits of using PLCL terpolymer as vascular biomaterial compared to PLLA.

引用

页码：1392 / 1410

页数：19