Essential functions of regulatory T cell TGF-β1 revealed by differential gene-targeting approaches

被引：7
|
作者：
Stephen-Victor, Emmanuel [1 ,2 ]
Cui, Ye [1 ,2 ]
Wang, Ziwei [1 ]
Benamar, Mehdi [1 ,2 ]
Charbonnier, Louis-Marie [1 ,2 ]
Chatila, Talal A. [1 ,2 ]
机构：
[1] Boston Childrens Hosp, Div Immunol, Boston, MA 02115 USA
[2] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA
来源：
IMMUNITY | 2021年 / 54卷 / 03期
关键词：
D O I：
10.1016/j.immuni.2021.02.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：397 / 398
页数：2
相关论文
共 50 条
  • [31] TGF-β SIGNALING IN T CELLS IS NOT ESSENTIAL FOR TH17 CELL DEVELOPMENT IN THE MOUSE
    Schumann, J.
    Mueller, U.
    Blessing, M.
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2012, 26 (03): : 357 - 366
  • [32] Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting
    Muramatsu, T
    JOURNAL OF BIOCHEMISTRY, 2000, 127 (02): : 171 - 176
  • [33] Allograft transplantation provokes miRNA 297-669 cluster that reduces T regulatory cell generation through targeting TGF-β2
    Becker, William J.
    Nagarkatti, Prakash
    Nagarkatti, Mitzi
    JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
  • [34] Defective CD4+CD25+ T-regulatory cell ability to induce TGF-β secretion in autoimmune hepatitis is associated with reduced level of TGF-β gene expression
    Longhi, M. S.
    Mitry, R. R.
    Mieli-Vergani, G.
    Vergani, D.
    Ma, Y.
    JOURNAL OF HEPATOLOGY, 2006, 44 : S238 - S239
  • [35] Dendritic cell-derived TGF-β mediates the induction of mucosal regulatory T-cell response toHelicobacterinfection essential for maintenance of immune tolerance in mice
    Owyang, Stephanie Y.
    Zhang, Min
    El-Zaatari, Mohamad
    Eaton, Kathryn A.
    Bishu, Shrinivas
    Hou, Guoqing
    Grasberger, Helmut
    Kao, John Y.
    HELICOBACTER, 2020, 25 (06)
  • [36] Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β
    Jang, Young-Saeng
    Song, Ha-Eon
    Seo, Goo-Young
    Jo, Hyeon-Ju
    Park, Sunhee
    Park, Hui-Won
    Kim, Tae-Gyu
    Kang, Seung-Goo
    Yoon, Sung-Il
    Ko, Hyun-Jeong
    Lee, Geun-Shik
    Park, Seok-Rae
    Kim, Pyeung-Hyeun
    JOURNAL OF IMMUNOLOGY, 2021, 207 (10): : 2456 - 2464
  • [37] Differential Gene Expression Analysis Reveals Global LMTK2 Regulatory Network and Its Role in TGF-β1 Signaling
    Cruz, Daniel F.
    Mitash, Nilay
    Mu, Fangping
    Farinha, Carlos M.
    Swiatecka-Urban, Agnieszka
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [38] MicroRNAs targeting TGFβ signalling underlie the regulatory T cell defect in multiple sclerosis
    Severin, Mary E.
    Lee, Priscilla W.
    Liu, Yue
    Selhorst, Amanda J.
    Gormley, Matthew G.
    Pei, Wei
    Yang, Yuhong
    Guerau-de-Arellano, Mireia
    Racke, Michael K.
    Lovett-Racke, Amy E.
    BRAIN, 2016, 139 : 1747 - 1761
  • [39] The Transforming Growth Factor-β1 (TGF-β1) Gene Polymorphisms (TGF-β1 T869C and TGF-β1 T29C) and Susceptibility to Postmenopausal Osteoporosis A Meta-Analysis
    Sun, Jiajia
    Zhang, Chi
    Xu, Lei
    Yang, Mingyuan
    Yang, Huilin
    MEDICINE, 2015, 94 (04)
  • [40] Association of TGF-β1 gene polymorphisms in exon1 and blood levels with essential hypertension
    He, Fang
    Zhao, Dan
    Deng, Fengmei
    Zhong, Hua
    Shi, Xiaopeng
    Yang, Jianfeng
    Guo, Shuxia
    Cheng, Jiang
    Huang, Gang
    Tang, Bin
    Wang, Zhenhuan
    Chen, Xiongying
    Wang, Gang
    Zhang, Wanjiang
    Zhang, Chunjun
    Wang, Xuewen
    Hu, Qinghua
    BLOOD PRESSURE, 2010, 19 (04) : 225 - 233
12345