Liquid Biopsies and Cancer Immunotherapy

被引：18
作者：
Thompson, Jonathan R. [1 ]
Menon, Smitha P. [1 ]
机构：
[1] Med Coll Wisconsin, Dept Med, Div Hematol & Oncol, Milwaukee, WI 53226 USA
来源：
CANCER JOURNAL | 2018年 / 24卷 / 02期
关键词：
Immunotherapy; tumor microenvironment; immune checkpoint inhibitor; tumor mutation burden; CIRCULATING TUMOR DNA; PROGRESSION-FREE SURVIVAL; DROPLET DIGITAL PCR; REGULATORY T-CELLS; PD-1; BLOCKADE; PERIPHERAL-BLOOD; INDUCE APOPTOSIS; OPEN-LABEL; NIVOLUMAB; PEMBROLIZUMAB;
D O I：
10.1097/PPO.0000000000000307
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer immunotherapy has recently undergone rapid advances and has become an integral part of the treatment armamentarium in various malignancies. However, tissue-based biomarker development in this arena has been slow, and valid biomarker identification to guide immunotherapeutic management is desperately needed. "Liquid" or blood-based biopsies potentially offer more convenient and efficient means to judge the immune milieu of individual patients and identify who will benefit most from immunotherapy. The following review highlights the current literature regarding the application of liquid biopsies to cancer immunotherapy.
引用
收藏
页码：78 / 83
页数：6
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