Type 1 diabetes: Through the lens of human genome and metagenome interplay

被引：13
作者：
Vahed, Sepideh Zununi [1 ]
Sani, Hakimeh Moghaddas [1 ]
Saadat, Yalda Rahbar [2 ]
Barzegari, Abolfazl [2 ]
Omidi, Yadollah [2 ,3 ]
机构：
[1] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Biomed Inst, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Pharm, Dept Pharmaceut, Tabriz, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 104卷
关键词：
Diabetes; Immune system; Microbiota; Probiotic; Mucosal immunity; REGULATORY T-CELLS; GUT MICROBIOTA; INTESTINAL MICROBIOTA; LACTOBACILLUS-CASEI; COMMENSAL BACTERIA; IMMUNE-RESPONSE; DELIVERY MODE; ONSET; RISK; AUTOIMMUNITY;
D O I：
10.1016/j.biopha.2018.05.052
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Diabetes is a genetic- and epigenetic- related disease from which a large population worldwide suffers. Some genetic factors along with various mutations related to the immune system for disease mechanism(s) have contrastively been determined. However, sometimes mechanisms have not been fully managed for the clarification of the initiation and/or progression of diseases to help patients. In the recent years, due to familiarity with the role of gut microbiota in the health, it has been found that the changes of the microbial balance in the industrialized societies can cause a battery of modern diseases, for which we have no specific definition of how they emerge. This work aims to explore the relationship between the human gut microbiota and the immune system along with their possible role in avoiding/emerging of type 1 diabetes (T1D) accompanied with the relation between genome and metagenome and their imbalance in causing T1D. Moreover, it provides novel view on how to balance the intestinal microbiota by lifestyle to hinder the mechanisms leading to T1D.
引用
收藏
页码：332 / 342
页数：11
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