Epidemiology of multiple system atrophy: A prevalence and pilot risk factor study in Aquitaine, France

被引：57
作者：
Chrysostome, V
Tison, F
Yekhlef, F
Sourgen, C
Baldi, I
Dartigues, JF
机构：
[1] Ctr Hosp Univ Bordeaux, Federat Neurol, Bordeaux, France
[2] Ctr Hosp Univ Bordeaux, INSERM, U330, Bordeaux, France
[3] Ctr Hosp Univ Bordeaux, Lab Work Hlth & Environm, Bordeaux, France
来源：
NEUROEPIDEMIOLOGY | 2004年 / 23卷 / 04期
关键词：
multiple system atrophy; prevalence; risk factors; pesticides;
D O I：
10.1159/000078506
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
We investigated the prevalence of multiple system atrophy (MSA) in Gironde, France, through a network of 120 public and private specialists and assessed the relationship between some environmental factors and MSA in a case-control study involving 50 MSA patients, 50 Parkinson's disease (PD) patients and 50 healthy controls. The occupational exposure to pesticides was evaluated through a job-exposure matrix. On prevalence day (November 1, 1998), the crude prevalence of MSA in Gironde was 1.94/100,000 inhabitants. We found no significant relationship between occupational exposure to pesticides and MSA. PD patients were significantly less frequently ever-smokers than controls and the same tendency was observed for MSA patients. We also described the clinical features that heralded the disease among this nonselected population. Copyright (C) 2004 S. Karger AG, Basel.
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收藏
页码：201 / 208
页数：8
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