The Microbiome in Psychology and Cognitive Neuroscience

被引：152

作者：

Sarkar, Amar ^{[1
,2
,3
]}

Harty, Siobhan ^{[1
,4
,5
]}

Lehto, Soili M. ^{[6
,7
,8
]}

Moeller, Andrew H. ^{[9
]}

Dinan, Timothy G. ^{[10
,11
]}

Dunbar, Robin I. M. ^{[1
]}

Cryan, John F. ^{[11
,12
]}

Burnet, Philip W. J. ^{[13
]}

机构：

[1] Univ Oxford, Dept Expt Psychol, Oxford, England

[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England

[3] Univ Cambridge, Trinity Coll, Cambridge, England

[4] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin 2, Ireland

[5] Trinity Coll Dublin, Sch Psychol, Dublin 2, Ireland

[6] Univ Helsinki, Dept Psychol & Logoped, Fac Med, Helsinki, Finland

[7] Univ Eastern Finland, Inst Clin Med Psychiat, Kuopio, Finland

[8] Kuopio Univ Hosp, Dept Psychiat, Kuopio, Finland

[9] Univ Calif Berkeley, Miller Inst Basic Res Sci, Berkeley, CA 94720 USA

[10] Univ Coll Cork, APC Microbiome Inst, Cork, Ireland

[11] Univ Coll Cork, Dept Psychiat & Neurobehav Sci, Cork, Ireland

[12] Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland

[13] Univ Oxford, Dept Psychiat, Oxford, England

来源：

TRENDS IN COGNITIVE SCIENCES | 2018年 / 22卷 / 07期

基金：

爱尔兰科学基金会; 英国生物技术与生命科学研究理事会;

关键词：

CENTRAL-NERVOUS-SYSTEM; ANXIETY-LIKE BEHAVIOR; HISTONE DEACETYLASE INHIBITOR; MAJOR DEPRESSIVE DISORDER; ELEVATED PLUS-MAZE; GUT MICROBIOTA; FECAL MICROBIOTA; LACTOBACILLUS-HELVETICUS; SODIUM-BUTYRATE; FERMENTED MILK;

D O I：

10.1016/j.tics.2018.04.006

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Psychology and microbiology make unlikely friends, but the past decade has witnessed striking bidirectional associations between intrinsic gut microbes and the brain, relationships with largely untested psychological implications. Although microbe-brain relationships are receiving a great deal of attention in biomedicine and neuroscience, psychologists have yet to join this journey. Here, we illustrate microbial associations with emotion, cognition, and social behavior. However, despite considerable enthusiasm and potential, technical and conceptual limitations including low statistical power and lack of mechanistic descriptions prevent a nuanced understanding of microbiome-brain-behavior relationships. Our goal is to describe microbial effects in domains of cognitive significance and the associated challenges to stimulate interdisciplinary research on the contribution of this hidden kingdom to psychological processes.

引用

页码：611 / 636

页数：26

共 226 条

[1] Gastrointestinal flora and gastrointestinal status in children with autism-comparisons to typical children and correlation with autism severity [J].

Adams, James B. ;

Johansen, Leah J. ;

Powell, Linda D. ;

Quig, David ;

Rubin, Robert A. .

BMC GASTROENTEROLOGY, 2011, 11

[2] Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats [J].

Ait-Belgnaoui, Afifa ;

Durand, Henri ;

Cartier, Christel ;

Chaumaz, Gilles ;

Eutamene, Helene ;

Ferrier, Laurent ;

Houdeau, Eric ;

Fioramonti, Jean ;

Bueno, Lionel ;

Theodorou, Vassilia .

PSYCHONEUROENDOCRINOLOGY, 2012, 37 (11) :1885-1895

[3] Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial [J].

Akkasheh, Ghodarz ;

Kashani-Poor, Zahra ;

Tajabadi-Ebrahimi, Maryam ;

Jafari, Parvaneh ;

Akbari, Hossein ;

Taghizadeh, Mohsen ;

Memarzadeh, Mohammad Reza ;

Asemi, Zatollah ;

Esmaillzadeh, Ahmad .

NUTRITION, 2016, 32 (03) :315-320

[4] Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers [J].

Allen, A. P. ;

Hutch, W. ;

Borre, Y. E. ;

Kennedy, P. J. ;

Temko, A. ;

Boylan, G. ;

Murphy, E. ;

Cryan, J. F. ;

Dinan, T. G. ;

Clarke, G. .

TRANSLATIONAL PSYCHIATRY, 2016, 6 :e939-e939

[5]

Allen AP, 2017, SOC PERSONAL PSYCHOL, V11, DOI 10.1111/spc3.12309

[6] Video game training enhances cognitive control in older adults [J].

Anguera, J. A. ;

Boccanfuso, J. ;

Rintoul, J. L. ;

Al-Hashimi, O. ;

Faraji, F. ;

Janowich, J. ;

Kong, E. ;

Larraburo, Y. ;

Rolle, C. ;

Johnston, E. ;

Gazzaley, A. .

NATURE, 2013, 501 (7465) :97-+

[7]

Arentsen Tim, 2015, Microbial Ecology in Health and Disease, V26, P29719, DOI 10.3402/mehd.v26.29719

[8] Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome [J].

Ashwood, Paul ;

Krakowiak, Paula ;

Hertz-Picciotto, Irva ;

Hansen, Robin ;

Pessah, Isaac ;

Van de Water, Judy .

BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (01) :40-45

[9] The immune response in autism: a new frontier for autism research [J].

Ashwood, Paul ;

Wills, Sharifia ;

Van De Water, Judy .

JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 80 (01) :1-15

[10] Prenatal stress alters bacterial colonization of the gut in infant monkeys [J].

Bailey, MT ;

Lubach, GR ;

Coe, CL .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2004, 38 (04) :414-421

← 1 2 3 4 5 6 7 8 9 10 →