Immune responses to Neospora caninum and prospects for vaccination

被引：169

作者：

Innes, EA ^{[1
]}

Andrianarivo, AG

Björkman, C

Williams, DJL

Conrad, PA

机构：

[1] Moredun Res Inst, Dept Parasitol, Edinburgh EH26 0PZ, Midlothian, Scotland

[2] Univ Calif Davis, Sch Vet Med, Dept Microbiol Pathol & Immunol, Davis, CA 95616 USA

[3] Swedish Univ Agr Sci, Dept Ruminant Med & Vet Epidemiol, SE-75007 Uppsala, Sweden

[4] Univ Liverpool, Dept Vet Parasitol, Liverpool L3 5QA, Merseyside, England

来源：

TRENDS IN PARASITOLOGY | 2002年 / 18卷 / 11期

关键词：

D O I：

10.1016/S1471-4922(02)02372-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Developing an effective vaccine against neosporosis presents several interesting challenges. The parasite is spread efficiently from mother to foetus over several generations, and naturally infected cattle do not appear to develop adequate protective immunity. Modulation of the immune response during pregnancy favours parasite survival and multiplication. However, induction of pro-inflammatory responses that are thought to be protective against Neospora caninum would be detrimental to the pregnancy. So, is vaccination a feasible option to control the disease? This article discusses some of these issues and reports on the progress towards a vaccine for neosporosis.

引用

页码：497 / 504

页数：8

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