Motor symptoms in Parkinsonism and Parkinson's disease

被引：1
|
作者：
Grabli, David [1 ,2 ]
机构：
[1] Univ La Sorbonne, UPMC Paris 06, CNRS UMR 7225, UMR S 1127,Inst Cerveau & Moelle,Inserm 1127 & CI, 47-83,Blvd lHopital, F-75013 Paris, France
[2] AP HP, Hopital Pitie Salpetriere, Dept Malad Syst Nerveux, F-75013 Paris, France
来源：
PRESSE MEDICALE | 2017年 / 46卷 / 02期
关键词：
PROGRESSION;
D O I：
10.1016/j.lpm.2017.01.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Parkinsonian syndrome is the clinical expression of a lesion within the nigro-striatal dopaminergic pathway. Akinesia is the main manifestation of parkinsonism. The clinical analysis of motor symptoms may guide clinical diagnosis. Parkinson's disease is characterized by a pure asymmetric parkinsonian syndrome, responsive to dopaminergic treatment. The evolution of Parkinson's disease is characterized by the occurrence of motor complications (dyskinesia and fluctuations). Gait disturbances (postural instability and freezing) are late in Parkinson's disease. When early (within the first three years), they point to atypical parkinsonian syndrome.
引用
收藏
页码：187 / 194
页数：8
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