Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation

被引：134
作者：
Jeong, Guan-Young [1 ]
Ricco, Raffaele [2 ]
Liang, Kang [2 ]
Ludwig, Johanna [2 ]
Kim, Jin-Oh [1 ]
Falcaro, Paolo [2 ]
Kim, Dong-Pyo [1 ]
机构：
[1] Pohang Univ Sci & Technol POSTECH, Dept Chem Engn, Pohang 790784, South Korea
[2] CSIRO, Mfg Flagship, Dickson, ACT 2602, Australia
来源：
CHEMISTRY OF MATERIALS | 2015年 / 27卷 / 23期
基金：
新加坡国家研究基金会;
关键词：
METAL-ORGANIC-FRAMEWORK; SELECTIVE OXIDATION; COMPOSITES; TEMPERATURE; IMMOBILIZATION; BIOCATALYSIS; DERIVATIVES; FLUORESCENT; PEROXIDASE; ULTRAFAST;
D O I：
10.1021/acs.chemmater.5b02847
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Functional bio-MOF hollow spheres with controlled size in the 35-2000 mu m range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanopartides (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.
引用
收藏
页码：7903 / 7909
页数：7
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