A concise total synthesis of the lichen macrolide (+)-aspicilin

被引：25
|
作者：
Dubost, Christophe
Marko, Istvan E. [1 ]
Ryckmans, Thomas
机构：
[1] Pfizer Ltd, Global Res & Dev, Sandwich CT13 9NJ, Kent, England
[2] Catholic Univ Louvain, Dept Chim, B-1348 Louvain, Belgium
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 22期
关键词：
STEREOSELECTIVE-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; OXIDATION; ARTICLE; ACIDS;
D O I：
10.1021/ol0620287
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of the polyhydroxylated macrolide (+)-aspicilin 5 is described using as a key step a highly diastereoselective allylation of aldehyde 6 with the uniquely functionalized allylstannane 1. (+)-Aspicilin is obtained in 18 steps and 10% overall yield.
引用
收藏
页码：5137 / 5140
页数：4
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