A concise total synthesis of the lichen macrolide (+)-aspicilin

被引：25

作者：

Dubost, Christophe

Marko, Istvan E. ^{[1
]}

Ryckmans, Thomas

机构：

[1] Pfizer Ltd, Global Res & Dev, Sandwich CT13 9NJ, Kent, England

[2] Catholic Univ Louvain, Dept Chim, B-1348 Louvain, Belgium

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 22期

关键词：

STEREOSELECTIVE-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; OXIDATION; ARTICLE; ACIDS;

D O I：

10.1021/ol0620287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the polyhydroxylated macrolide (+)-aspicilin 5 is described using as a key step a highly diastereoselective allylation of aldehyde 6 with the uniquely functionalized allylstannane 1. (+)-Aspicilin is obtained in 18 steps and 10% overall yield.

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收藏

页码：5137 / 5140

页数：4

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