Increased neutrophil to lymphocyte ratio predicts myocardial injury in patients undergoing non-cardiac surgery

被引:12
作者
Durmus, Gunduz [1 ]
Belen, Erdal [1 ]
Can, Mehmet Mustafa [1 ]
机构
[1] Haseki Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey
来源
HEART & LUNG | 2018年 / 47卷 / 03期
关键词
Electrocardiograph; High sensitive troponin T; Myocardial injury; Neutrophil to lymphocyte ratio; Non-cardiac surgery; CORONARY-ARTERY-DISEASE; INFARCTION; OUTCOMES; ASSOCIATION; COHORT; PATHOPHYSIOLOGY; ATHEROSCLEROSIS; INFLAMMATION; MORTALITY; SEVERITY;
D O I
10.1016/j.hrtlng.2018.01.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The neutrophil to lymphocyte ratio (NLR), has been proposed as potential indicator of cardiovascular events. Our aim was to determine the relationship between NLR and development of myocardial injury after non-cardiac surgery (MINS). Methods: This observational cohort study included 255 consecutive noncardiac surgery patients aged >= 45 years. Electrocardiography recordings and high sensitivity cardiac troponin T (hscTnT) levels of the patients were obtained for a period of 3 days postoperatively. Results: MINS was detected in 30 (11.8%) patients using the cut-off level of >= 14 ng/L for hscTnT. In the MINS group NLR (3.79 +/- 0.7 vs. 2.69 +/- 0.6, p < 0.000) values were higher than non-NLR group. The NLR to be independently associated with the development of MINS (OR: 11.690; CI: 4.619-29.585, p < 0.000). Conclusions: NLR seems to be a simple, easy and cheap tool to predict the development of MINS in patient undergoing non-cardiac surgery. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:243 / 247
页数:5
相关论文
共 31 条
[1]   Myocardial Injury after Noncardiac Surgery A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes [J].
Botto, Fernando ;
Alonso-Coello, Pablo ;
Chan, Matthew T. V. ;
Carlos Villar, Juan ;
Xavier, Denis ;
Srinathan, Sadeesh ;
Guyatt, Gordon ;
Cruz, Patricia ;
Graham, Michelle ;
Wang, C. Y. ;
Berwanger, Otavio ;
Pearse, Rupert M. ;
Biccard, Bruce M. ;
Abraham, Valsa ;
Malaga, German ;
Hillis, Graham S. ;
Rodseth, Reitze N. ;
Cook, Deborah ;
Polanczyk, Carisi A. ;
Szczeklik, Wojciech ;
Sessler, Daniel I. ;
Sheth, Tej ;
Ackland, Gareth L. ;
Leuwer, Martin ;
Garg, Amit X. ;
LeManach, Yannick ;
Pettit, Shirley ;
Heels-Ansdell, Diane ;
LuratiBuse, Giovanna ;
Walsh, Michael ;
Sapsford, Robert ;
Schuenemann, Holger J. ;
Kurz, Andrea ;
Thomas, Sabu ;
Mrkobrada, Marko ;
Thabane, Lehana ;
Gerstein, Hertzel ;
Paniagua, Pilar ;
Nagele, Peter ;
Raina, Parminder ;
Yusuf, Salim ;
Devereaux, P. J. ;
McQueen, Matthew J. ;
Bhandari, Mohit ;
Bosch, Jackie ;
Buckley, Norman ;
Chow, Clara K. ;
Halliwell, Richard ;
Li, Stephen ;
Lee, Vincent W. .
ANESTHESIOLOGY, 2014, 120 (03) :564-578
[2]   REGULATION OF IMMUNE-RESPONSE BY SUBCLASSES OF T-LYMPHOCYTES .1. INTERACTIONS BETWEEN PRE-KILLER T-CELLS AND REGULATORY T-CELLS OBTAINED FROM PERIPHERAL LYMPHOID-TISSUES OF MICE [J].
CANTOR, H ;
SIMPSON, E .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1975, 5 (05) :330-336
[3]   Value of Early Risk Stratification Using Hemoglobin Level and Neutrophil-to-Lymphocyte Ratio in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention [J].
Cho, Kyung Hoon ;
Jeong, Myung Ho ;
Ahmed, Khurshid ;
Hachinohe, Daisuke ;
Choi, Hong Sang ;
Chang, Soo Young ;
Kim, Min Chul ;
Hwang, Seung Hwan ;
Park, Keun-Ho ;
Lee, Min Goo ;
Ko, Jum Suk ;
Sim, Doo Sun ;
Yoon, Nam Sik ;
Yoon, Hyun Ju ;
Hong, Young Joon ;
Kim, Kye Hun ;
Kim, Ju Han ;
Ahn, Youngkeun ;
Cho, Jeong Gwan ;
Park, Jong Chun ;
Kang, Jung Chaee .
AMERICAN JOURNAL OF CARDIOLOGY, 2011, 107 (06) :849-856
[4]   Effects of extended-release metoprolol succinate inpatients undergoing non-cardiac surgery (POISE trial):: a randomised controlled trial [J].
Devereaux, P. J. ;
Yang, Homer ;
Yusuf, Salim ;
Guyatt, Gordon ;
Leslie, Kate ;
Villar, Juan Carlos ;
Xavier, Denis ;
Chrolavicius, Susan ;
Greenspan, Launi ;
Pogue, Janice ;
Pais, Prem ;
Liu, Lisheng ;
Xu, Shouchun ;
Malaga, German ;
Avezum, Alvaro ;
Chan, Matthew ;
Montori, Victor M. ;
Jacka, Mike ;
Choi, Peter .
LANCET, 2008, 371 (9627) :1839-1847
[5]   Association Between Postoperative Troponin Levels and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery [J].
Devereaux, P. J. ;
Chan, Matthew T. V. ;
Alonso-Coello, Pablo ;
Walsh, Michael ;
Berwanger, Otavio ;
Villar, Juan Carlos ;
Wang, C. Y. ;
Garutti, R. Ignacio ;
Jacka, Michael J. ;
Sigamani, Alben ;
Srinathan, Sadeesh ;
Biccard, Bruce M. ;
Chow, Clara K. ;
Abraham, Valsa ;
Tiboni, Maria ;
Pettit, Shirley ;
Szczeklik, Wojciech ;
Buse, Giovanna Lurati ;
Botto, Fernando ;
Guyatt, Gordon ;
Heels-Ansdell, Diane ;
Sessler, Daniel I. ;
Thorlund, Kristian ;
Garg, Amit X. ;
Mrkobrada, Marko ;
Thomas, Sabu ;
Rodseth, Reitze N. ;
Pearse, Rupert M. ;
Thabane, Lehana ;
McQueen, Matthew J. ;
VanHelder, Tomas ;
Bhandari, Mohit ;
Bosch, Jackie ;
Kurz, Andrea ;
Polanczyk, Carisi ;
Malaga, German ;
Nagele, Peter ;
Le Manach, Yannick ;
Leuwer, Martin ;
Yusuf, Salim .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (21) :2295-2304
[6]   Characteristics and Short- Term Prognosis of Perioperative Myocardial Infarction in Patients Undergoing Noncardiac Surgery A Cohort Study [J].
Devereaux, P. J. ;
Xavier, Denis ;
Pogue, Janice ;
Guyatt, Gordon ;
Sigamani, Alben ;
Garutti, Ignacio ;
Leslie, Kate ;
Rao-Melacini, Purnima ;
Chrolavicius, Sue ;
Yang, Homer ;
MacDonald, Colin ;
Avezum, Alvaro ;
Lanthier, Luc ;
Hu, Weijiang ;
Yusuf, Salim .
ANNALS OF INTERNAL MEDICINE, 2011, 154 (08) :523-528
[7]   Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk [J].
Devereaux, PJ ;
Goldman, L ;
Cook, DJ ;
Gilbert, K ;
Leslie, K ;
Guyatt, GH .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2005, 173 (06) :627-634
[8]   Relationship Between Neutrophil-to-Lymphocyte Ratio and Saphenous Vein Graft Disease in Patients With Coronary Bypass [J].
Dogan, Mehmet ;
Akyel, Ahmet ;
Cimen, Tolga ;
Oksuz, Fatih ;
Celik, Ibrahim Etem ;
Ayturk, Mehmet ;
Murat, Sani Namik ;
Yeter, Ekrem .
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2015, 21 (01) :25-29
[9]   Analytical Validation of a High-Sensitivity Cardiac Troponin T Assay [J].
Giannitsis, Evangelos ;
Kurz, Kerstin ;
Hallermayer, Klaus ;
Jarausch, Jochen ;
Jaffe, Allan S. ;
Katus, Hugo A. .
CLINICAL CHEMISTRY, 2010, 56 (02) :254-261
[10]   Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting [J].
Gibson, Patrick H. ;
Croal, Bernard L. ;
Cuthbertson, Brian H. ;
Small, Gary R. ;
Ifezulike, Adaeze I. ;
Gibson, George ;
Jeffrey, Robert R. ;
Buchan, Keith G. ;
El-Shafei, Hussein ;
Hillis, Graham S. .
AMERICAN HEART JOURNAL, 2007, 154 (05) :995-1002