Tachyphylaxis and sensitization to nicotine-induced tachycardiac and pressor effects after nicotine infusions

被引:0
|
作者
Cruz, SL
Vidrio, H
机构
[1] UNIV NACL AUTONOMA MEXICO,FAC MED,DEPT FARMACOL,MEXICO CITY 04510,DF,MEXICO
[2] IPN,CINVESTAV,DEPT FARMACOL & TOXICOL,SECC TERAPEUT EXPT,MEXICO CITY 07738,DF,MEXICO
来源
ARCHIVES OF MEDICAL RESEARCH | 1997年 / 28卷 / 02期
关键词
nicotine; blood pressure; heart rate; tolerance; sensitization;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This work examined the effects of nicotine on mean arterial pressure and heart rate in non-anesthetized spinal rats. Nicotine (200 mg/kg) was administered as a single bolus, as infusions lasting 7.5, 15 or 30 min, and as a post-infusion bolus. A nicotine bolus increased pressure and rate, These effects were less marked as the rate of infusion decreased. The infusions affected differentially the effects of a subsequent bolus. Thus, while tachycardia was decreased, the blood pressure rise was increased. An initial transient bradycardia was observed after bolus administration, but not during infusions; this effect was unchanged after post-infusion boluses, Pharmacological analysis indicated that tachycardia and bradycardia were predominantly due to ganglionic stimulation, while adrenal;and sympathetic nerve catecholamine release played a major role in the presser response. These results indicate that stow nicotine infusions do not induce tachyphylaxis for all of the cardiovascular effects of a subsequent bolus, and that development of acute tolerance appears to depend on the mechanism of action of the response.
引用
收藏
页码:189 / 194
页数:6
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