The mechanism of B-A transition in DNA molecule: Elastic interactions between sugars and nitrous bases

被引：0

作者：

Ponomarev, VO ^{[1
]}

Shikhovtseva, ES ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Res Ctr, Inst Phys Mol & Crystals, Ufa 450075, Russia

来源：

BIOFIZIKA | 2000年 / 45卷 / 01期

关键词：

DNA; molecule; B -> A transition; two-component model; soliton;

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A two-component model with elastic interactions between subsystems was proposed, which describes conformational transitions in the DNA molecule. The model is applicable for the description of B-->A transitions in the DNA molecule. It is shown that conformational excitations propagate along the macromolecule via stable topological solitons having a definite velocity. Two types of solitons can be distinguished: exciting and reducing. The exciting soliton realizes the transition of sugar from the ground state to a metastable state; in this process, the distance between complementary bases increases. The reducing soliton is formed behind the exciting soliton and realizes a reverse transition.

引用

页码：27 / 31

页数：5

共 20 条

[1] PRESENCE OF NONLINEAR EXCITATIONS IN DNA-STRUCTURE AND THEIR RELATIONSHIP TO DNA PREMELTING AND TO DRUG INTERCALATION [J].

BANERJEE, A ;

SOBELL, HM .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1983, 1 (01) :253-262

[2]

Bishop A. R., 1980, Physica D, V1D, P1, DOI 10.1016/0167-2789(80)90003-2

[3] GENETIC-REGULATION - LAC CONTROL REGION [J].

DICKSON, RC ;

ABELSON, J ;

BARNES, WM ;

REZNIKOFF, WS .

SCIENCE, 1975, 187 (4171) :27-35

[4] SOLITARY WAVES IN ONE-DIMENSIONAL DAMPED SYSTEMS [J].

GONZALEZ, JA ;

HOLYST, JA .

PHYSICAL REVIEW B, 1987, 35 (07) :3643-3646

[5] TRANSMISSION OF ALLOSTERIC EFFECTS IN DNA [J].

HOGAN, M ;

DATTAGUPTA, N ;

CROTHERS, DM .

NATURE, 1979, 278 (5704) :521-524

[6]

IVANOV V I, 1983, Molekulyarnaya Biologiya (Moscow), V17, P616

[7] CONFORMATIONAL POSSIBILITIES OF DOUBLE-HELICAL NUCLEIC-ACIDS - THEORY AND EXPERIMENT [J].

IVANOV, VI ;

ZHURKIN, VB ;

ZAVRIEV, SK ;

LYSOV, YP ;

MINCHENKOVA, LE ;

MINYAT, EE ;

FRANKKAMENETSKII, MD ;

SCHYOLKINA, AK .

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 1979, 16 (01) :189-201

[8]

IVANOV VI, 1985, BIOPOLIMERY KLETKA, V1, P5

[9] DYNAMICS AND STATISTICAL-MECHANICS OF A ONE-DIMENSIONAL MODEL HAMILTONIAN FOR STRUCTURAL PHASE-TRANSITIONS [J].

KRUMHANSL, JA ;

SCHRIEFFER, JR .

PHYSICAL REVIEW B, 1975, 11 (09) :3535-3545

[10]

Krumhansl JA., 1983, STRUCTURE DYNAMICS N, P61

← 1 2 →