A new method of forming resin bound thioesters and their use as 'traceless' linkers in solid phase synthesis

被引：29
作者：
May, PJ
Bradley, M [1 ]
Harrowven, DC
Pallin, D
机构：
[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England
[2] Rhone Poulenc Rorer Ltd, Dagenham Res Ctr, Dagenham RM10 7XS, Essex, England
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
combinatorial chemistry; lactones; solid phase synthesis; thioamide; thioester;
D O I：
10.1016/S0040-4039(99)02345-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Resin bound thioesters can be prepared by heating thioamides in aqueous DMF with Merrifield resin in the presence of sodium iodide. These thioamides can be cleaved to give alcohols, ketones and lactones by a variety of methods. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1627 / 1630
页数：4
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