Synthesis of Fluorinated β-Ketosulfones and gem-Disulfones by Nucleophilic Fluoroalkylation of Esters and Sulfinates with Di- and Monofluoromethyl Sulfones

被引：40
作者：
Ni, Chuanfa [1 ]
Zhang, Laijun [1 ]
Hu, Jinbo [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 10期
基金：
中国国家自然科学基金;
关键词：
DIFLUOROMETHYL PHENYL SULFONE; TRIFLUOROMETHYL KETONES; CONVENIENT SYNTHESIS; (TRIFLUOROMETHYL)TRIMETHYLSILANE; EFFICIENT; ALDEHYDES; ALCOHOLS; ALPHA; ALPHA-DIFLUORO-BETA-KETOPHOSPHONATES; FLUOROBIS(PHENYLSULFONYL)METHANE; INHIBITORS;
D O I：
10.1021/jo900320b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and practically useful method for the preparation of alpha-functionalized mono- and difluoro(phenylsulfonyl)methanes by using a nucleophilic fluoroalkylation methodology was developed. alpha,alpha-Difluoro-P-ketosulfones, alpha-monofluoro-beta-ketosulfones, and alpha-fluoro disulfones were successfully prepared in excellent yields by nucleophilic fluoroalkylation of esters and sulfinates with PhSO2CF2H and PhSO2CH2F reagents.
引用
收藏
页码：3767 / 3771
页数：5
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