Synaptic plasticity: one STEP at a time

被引：85
作者：
Braithwaite, Steven P.
Paul, Surojit
Nairn, Angus C.
Lombroso, Paul J.
机构：
[1] AGY Therapeut Inc, San Francisco, CA 94080 USA
[2] Univ New Mexico, Dept Neurol, Albuquerque, NM 87131 USA
[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
[4] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA
来源：
TRENDS IN NEUROSCIENCES | 2006年 / 29卷 / 08期
关键词：
D O I：
10.1016/j.tins.2006.06.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial player in the regulation of synaptic function. It is restricted to neurons within the CNS and acts by downregulating the activity of MAP kinases, the tyrosine kinase Fyn and NMDA receptors. By modulating these substrates, STEP acts on several parallel pathways that impact upon the progression of synaptic plasticity. Here, we review recent advances that demonstrate the importance of STEP in normal cognitive function, and its possible involvement in cognitive disorders such as Alzheimer's disease.
引用
收藏
页码：452 / 458
页数：7
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