The role of stereotactic body radiotherapy and stereotactic radiosurgery in the re-irradiation of metastatic spinal tumors

被引:9
作者
Jain, Anshu K. [1 ,2 ]
Yamada, Yoshiya [3 ]
机构
[1] Columbia Univ, Med Ctr, Dept Radiat Oncol, New York, NY 10032 USA
[2] New York Presbyterian Hosp, New York, NY 10032 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10065 USA
关键词
re-irradiation; spinal cord tolerance; spinal metastases; stereotactic body radiotherapy; stereotactic radiosurgery; VERTEBRAL COMPRESSION FRACTURE; INTENSITY-MODULATED RADIOTHERAPY; INSTABILITY NEOPLASTIC SCORE; CORD COMPRESSION; RADIATION-THERAPY; CONFORMAL RADIOTHERAPY; CLINICAL-EXPERIENCE; NORMAL TISSUE; PAIN-CONTROL; SWINE MODEL;
D O I
10.1586/14737140.2014.940326
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) are advanced radiotherapy delivery techniques that allow for the delivery of high-dose per fraction radiation. Advances in imaging technology and intensity modulation have allowed SRS and SBRT to be used for the treatment of tumors in close proximity to the spinal cord and cauda equina, in particular spinal metastases. While the initial treatment of spinal metastases is often conventional palliative radiotherapy, treatment failure is not uncommon, and conventional re-irradiation may not be feasible due to spinal cord tolerance. SBRT and SRS have emerged as important techniques for the treatment of spinal metastases in the proximity of previously irradiated spinal cord. Here we review the current data on the use of SBRT and SRS spinal re-irradiation, and future directions for these important treatment modalities.
引用
收藏
页码:1141 / 1152
页数:12
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