Aged Human Thymus Hassall's Corpuscles are Immunoreactive for IGF-I and IGF-I Receptor

被引：5
|
作者：
Marinova, Tsvetana Ts. [1 ]
Spassov, Lyubomir D. [2 ,3 ]
Vlassov, Veselin I. [2 ,3 ]
Pashev, Vili V. [2 ,3 ]
Markova, Maya D. [4 ]
Ganev, Varban S. [1 ]
Dzhupanova, Ralitsa S. [1 ]
Angelov, Doychin N. [5 ]
机构：
[1] Sofia Univ St Kliment Ohridski, Fac Med, Dept Biol Med Genet & Microbiol, BG-1407 Sofia, Bulgaria
[2] Sofia Univ St Kliment Ohridski, Fac Med, Univ Hosp Lozenets, Surg Clin, BG-1407 Sofia, Bulgaria
[3] Sofia Univ St Kliment Ohridski, Fac Med, Univ Hosp Lozenets, Div Pathol, BG-1407 Sofia, Bulgaria
[4] Med Univ Sofia, Fac Med, Dept Biol, Sofia, Bulgaria
[5] Univ Cologne, Dept Anat 1, Inst Anat, D-50931 Cologne, Germany
来源：
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2009年 / 292卷 / 07期
关键词：
human; thymus; Hassall's corpuscles; IGF-I; IGF-IR; electron microscopy; GROWTH-FACTOR AXIS; MYASTHENIA-GRAVIS; NGF RECEPTORS; EXPRESSION; INVOLUTION; CELL; MICROENVIRONMENT; LOCALIZATION; INVOLVEMENT; PHYSIOLOGY;
D O I：
10.1002/ar.20920
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Although Hassall's corpuscles have been proposed to act in both maturation of developing thymocytes and removal of apoptotic cells, their function remains an enigma. The involvement of insulin-like growth factor I (IGF-I) in the local autocrine and paracrine control of T-cell development in human thymus is still unclear. In this study, we investigated the structure and distribution of IGF-I and IGF-I receptor (IGF-lR)-immunopositive Hassall's corpuscles in aged human thymus using bright-field immunohistochemistry and immunoelectron microscopy. We report new immunocytochemical data for the presence of IGF-I/IGF-IR double-immunopositive Hassall's corpuscles in structurally preserved regions of age-involuted thymus and discuss the involvement of these unique thymic components in the local regulation of T-cell development and thymus plasticity during aging by IGF-I/IGF-IR-mediated cell signaling pathway. Anat Rec, 292:960-965, 2009. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：960 / 965
页数：6
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