Aged Human Thymus Hassall's Corpuscles are Immunoreactive for IGF-I and IGF-I Receptor

被引：5
|
作者：
Marinova, Tsvetana Ts. [1 ]
Spassov, Lyubomir D. [2 ,3 ]
Vlassov, Veselin I. [2 ,3 ]
Pashev, Vili V. [2 ,3 ]
Markova, Maya D. [4 ]
Ganev, Varban S. [1 ]
Dzhupanova, Ralitsa S. [1 ]
Angelov, Doychin N. [5 ]
机构：
[1] Sofia Univ St Kliment Ohridski, Fac Med, Dept Biol Med Genet & Microbiol, BG-1407 Sofia, Bulgaria
[2] Sofia Univ St Kliment Ohridski, Fac Med, Univ Hosp Lozenets, Surg Clin, BG-1407 Sofia, Bulgaria
[3] Sofia Univ St Kliment Ohridski, Fac Med, Univ Hosp Lozenets, Div Pathol, BG-1407 Sofia, Bulgaria
[4] Med Univ Sofia, Fac Med, Dept Biol, Sofia, Bulgaria
[5] Univ Cologne, Dept Anat 1, Inst Anat, D-50931 Cologne, Germany
来源：
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2009年 / 292卷 / 07期
关键词：
human; thymus; Hassall's corpuscles; IGF-I; IGF-IR; electron microscopy; GROWTH-FACTOR AXIS; MYASTHENIA-GRAVIS; NGF RECEPTORS; EXPRESSION; INVOLUTION; CELL; MICROENVIRONMENT; LOCALIZATION; INVOLVEMENT; PHYSIOLOGY;
D O I：
10.1002/ar.20920
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Although Hassall's corpuscles have been proposed to act in both maturation of developing thymocytes and removal of apoptotic cells, their function remains an enigma. The involvement of insulin-like growth factor I (IGF-I) in the local autocrine and paracrine control of T-cell development in human thymus is still unclear. In this study, we investigated the structure and distribution of IGF-I and IGF-I receptor (IGF-lR)-immunopositive Hassall's corpuscles in aged human thymus using bright-field immunohistochemistry and immunoelectron microscopy. We report new immunocytochemical data for the presence of IGF-I/IGF-IR double-immunopositive Hassall's corpuscles in structurally preserved regions of age-involuted thymus and discuss the involvement of these unique thymic components in the local regulation of T-cell development and thymus plasticity during aging by IGF-I/IGF-IR-mediated cell signaling pathway. Anat Rec, 292:960-965, 2009. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：960 / 965
页数：6
相关论文
共 50 条
  • [1] IGF-I AND THE IGF-I RECEPTOR IN DEVELOPMENT OF NONMAMMALIAN VERTEBRATES
    DEPABLO, F
    PEREZVILLAMIL, B
    SERNA, J
    GONZALEZGUERRERO, PR
    LOPEZCARRANZA, A
    DELAROSA, EJ
    ALEMANY, J
    CALDES, T
    MOLECULAR REPRODUCTION AND DEVELOPMENT, 1993, 35 (04) : 427 - 433
  • [2] AUTOCRINE GROWTH OF CELLS OVEREXPRESSING THE HUMAN IGF-I AND IGF-I RECEPTOR GENES
    PIETRZKOWSKI, Z
    ULLRICH, A
    BASERGA, R
    FASEB JOURNAL, 1991, 5 (06): : A1622 - A1622
  • [3] Role of IGF-I receptor insulin receptor hybrid in IGF-I signaling
    Takata, Y
    Imamura, T
    Usui, I
    Morioka, H
    Sasaoka, T
    Kobayashi, M
    DIABETES, 1996, 45 : 863 - 863
  • [4] IGF-I and IGF-I Receptor Polymorphisms Among Elite Swimmers
    Ben-Zaken, Sigal
    Meckel, Yoav
    Dror, Nitzan
    Nemet, Dan
    Eliakim, Alon
    PEDIATRIC EXERCISE SCIENCE, 2014, 26 (04) : 470 - 476
  • [5] IGF-I binding proteins, IGF-I binding protein mRNA and IGF-I receptor mRNA in rats with acute renal failure given IGF-I
    Bohé, J
    Ding, H
    Qing, DP
    Yoon, KW
    Hirschberg, R
    Wolfgang, GHI
    Kopple, JD
    KIDNEY INTERNATIONAL, 1998, 54 (04) : 1070 - 1082
  • [6] IGF-I, IGF-I receptor and IGF-I binding proteins in human retinal endothelial cell cultures from diabetic and nondiabetic donors
    Spoerri, PE
    Ellis, EA
    Tarnuzzer, RW
    Grant, MB
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 940 - 940
  • [7] IGF-I, IGF-II and IGF-I receptor localization during tongue myogenesis
    Mayo, ML
    Yamani, A
    Dalrymple, K
    Cunningham, L
    Bringas, P
    Shuler, CF
    JOURNAL OF DENTAL RESEARCH, 1998, 77 : 152 - 152
  • [8] The IGF-I/IGF-I receptor pathway: Implications in the pathophysiology of thyroid cancer
    Ciampolillo, A
    De Tullio, C
    Giorgino, F
    CURRENT MEDICINAL CHEMISTRY, 2005, 12 (24) : 2881 - 2891
  • [9] Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor
    Vieira, Marta
    Leal, Sonia S.
    Gomes, Claudio M.
    Saraiva, Maria Joao
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2016, 1862 (04): : 797 - 804
  • [10] Localization of IGF-I and IGF-I receptor mRNA in Sparus aurata larvae
    Funkenstein, B
    Almuly, R
    Chan, SJ
    GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1997, 107 (03) : 291 - 303
12345