Direct and indirect neurological, cognitive, and behavioral effects of COVID-19 on the healthy elderly, mild-cognitive-impairment, and Alzheimer's disease populations

被引:50
作者
Iodice, Francesco [1 ,2 ]
Cassano, Valeria [1 ]
Rossini, Paolo M. [1 ]
机构
[1] IRCCS San Raffaele Pisana, Dept Neurosci & Neurorehabil, Via Pisana 235, I-00163 Rome, Italy
[2] Policlin Agostino Gemelli IRCCS, Neurol Unit, Rome, Italy
关键词
COVID-19; Alzheimer's disease; Mild cognitive impairment; Behavioral effects; Anxiety; Depressive disorders; DEMENTIA; IMPACT;
D O I
10.1007/s10072-020-04902-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction Healthy elderly, mild cognitive impairment and Alzheimer's disease populations have been among the most affected in the early stages of the COVID-19 pandemic due to the direct effects of the virus, and numerous indirect effects now emerge and will have to be carefully assessed over time. Methods This article reviews the main articles that have been published so far about the direct and indirect effects of the COVID-19 pandemic on these particularly fragile populations. Results The pandemic associated to COVID-19 has shifted most of the health resources to the emergency area and has consequently left the three main medical areas dealing with the elderly population (oncology, time-dependent diseases and degenerative disease) temporarily "uncovered". In the phase following the emergency, it will be crucial to guarantee to each area the economic and organizational resources to quickly return to the level of support of the prepandemic state. Conclusions The emergency phase represented a significant occasion of discussion on the possibilities of telemedicine which will inevitably become increasingly important, but all the limits of its use in the elderly population have to be considered. In the post-lockdown recovery phase, alongside the classic medical evaluation, the psychological evaluation must become even more important for doctors caring about people with cognitive decline as well as with their caregivers.
引用
收藏
页码:455 / 465
页数:11
相关论文
共 55 条
[1]   COVID-19 Spiraling of Frailty in Older Italian Patients [J].
Abbatecola, A. M. ;
Antonelli-Incalzi, R. .
JOURNAL OF NUTRITION HEALTH & AGING, 2020, 24 (05) :453-455
[2]  
Alvarez M, 2020, KNOWLEDGE POLICY
[4]  
[Anonymous], 2014, EUR PSYCHIAT S1, DOI DOI 10.1016/S0924-9338(14)78073-3
[5]   Neurological manifestations in COVID-19 caused by SARS-CoV-2 [J].
Baig, Abdul Mannan .
CNS NEUROSCIENCE & THERAPEUTICS, 2020, 26 (05) :499-501
[6]   Severe Acute Respiratory Syndrome Coronavirus 2 is Penetrating to Dementia Research [J].
Bostanciklioglu, Mehmet .
CURRENT NEUROVASCULAR RESEARCH, 2020, 17 (04) :342-343
[7]   The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects [J].
Brenner, Steven R. .
JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (11) :2341-2342
[8]   The psychological impact of quarantine and how to reduce it: rapid review of the evidence [J].
Brooks, Samantha K. ;
Webster, Rebecca K. ;
Smith, Louise E. ;
Woodland, Lisa ;
Wessely, Simon ;
Greenberg, Neil ;
Rubin, Gideon James .
LANCET, 2020, 395 (10227) :912-920
[9]   Social consequences of COVID-19 in a low resource setting in Sierra Leone, West Africa [J].
Buonsenso, Danilo ;
Cinicola, Bianca ;
Raffaelli, Francesca ;
Sollena, Pietro ;
Iodice, Francesco .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 97 :23-26
[10]   Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia [J].
Cagnin, Annachiara ;
Di Lorenzo, Raffaele ;
Marra, Camillo ;
Bonanni, Laura ;
Cupidi, Chiara ;
Lagana, Valentina ;
Rubino, Elisa ;
Vacca, Alessandro ;
Provero, Paolo ;
Isella, Valeria ;
Vanacore, Nicola ;
Agosta, Federica ;
Appollonio, Ildebrando ;
Caffarra, Paolo ;
Pettenuzzo, Ilaria ;
Sambati, Renato ;
Quaranta, Davide ;
Guglielmi, Valeria ;
Logroscino, Giancarlo ;
Filippi, Massimo ;
Tedeschi, Gioacchino ;
Ferrarese, Carlo ;
Rainero, Innocenzo ;
Bruni, Amalia C. .
FRONTIERS IN PSYCHIATRY, 2020, 11 :1-15