Expression of ADP-ribosylation factor-like protein 8B mRNA in the brain is down-regulated in mice fed a high-fat diet

被引：7
作者：
Haraguchi, Tomoaki [1 ]
Yanaka, Noriyuki [1 ]
Nogusa, Yoshihito [1 ]
Sumiyoshi, Naoki [1 ]
Eguchi, Yuko [1 ]
Kato, Norihisa [1 ]
机构：
[1] Hiroshima Univ, Grad Sch Biosphere Sci, Dept Mol & Appl Biosci, Higashihiroshima 7398528, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 07期
关键词：
high fat diet; brain; ADP-ribosylation factor-like protein;
D O I：
10.1271/bbb.60168
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A differential display was performed to analyze differential gene expression in the brains of mice in association with dietary high beef-tallow. Consumption of a high beef-tallow diet downregulated the expression of ADP-ribosylation factor-like protein 8B (Arl8B) mRNA in the brain. Arl8B mRNA was widely expressed in the mouse brain, including primary neuronal cells. The current study indicates that green fluorescent protein-fused Arl8B protein accumulated at the growth cones in primary neuronal cells, and that protrusions of human embryonic kidney 293 (HEK293) cells were significantly elongated by overexpression of Arl8B, suggesting an important role of Arl8B in neurite formation.
引用
收藏
页码：1798 / 1802
页数：5
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