Signal transduction and regulation in bacteria

被引：0

作者：

Gilles, E. D. ^{[1
]}

机构：

[1] Max Planck Inst Dynam Complex Tech Syst, D-39106 Magdeburg, Germany

来源：

COMPUTERS & CHEMICAL ENGINEERING | 2006年 / 30卷 / 10-12期

关键词：

signal transduction; regulation; modularity;

D O I：

10.1016/j.compchemeng.2006.05.042

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

To understand both the complex structure and behavior of signal transduction and regulation in bacterial cells requires an overall holistic approach. Due to the multitude of interacting components an understanding of these processes just by reflection is not possible. Here, the aid of mathematical modeling is absolutely essential to confirm the available biological knowledge by system theoretical analysis. Two examples of a global regulatory system, namely catabolite repression in Escherichia coli and redox control in Rodospirillum rubrum are discussed and compared. The regulation of stress sigma factor sigma(S) in E. coli is then dealt with as an example of regulated gene expression combined with proteolysis. Finally, phototaxis in Halobacterium salinarum is considered as a representative of a bacterial signal transduction system. Important questions are related to the modularity and the hierarchical structure of these systems. The goal is to decompose a signaling or regulatory system into components of elementary signal transfer and to discover common features of there systems. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1687 / 1699

页数：13

共 17 条

[1]

BACKFISCH T, 2005, FOSBE C P

[2]

BARKAI M, 1997, NATURE, V387, P913

[3] Microaerophilic cooperation of reductive and oxidative pathways allows maximal photosynthetic membrane biosynthesis in Rhodospirillum rubrum [J].

Grammel, H ;

Gilles, ED ;

Ghosh, R .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2003, 69 (11) :6577-6586

[4] Signal transduction and regulatory mechanisms involved in control of the σS (RpoS) subunit of RNA polymerase [J].

Hengge-Aronis, R .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2002, 66 (03) :373-+

[5]

Hengge-Aronis R, 2000, BACTERIAL STRESS RESPONSES, P161

[6] Calculability analysis in underdetermined metabolic networks illustrated by a model of the central metabolism in purple nonsulfur bacteria [J].

Klamt, S ;

Schuster, S ;

Gilles, ED .

BIOTECHNOLOGY AND BIOENGINEERING, 2002, 77 (07) :734-751

[7]

Kremling A., 2004, IT-Information Technology, V46, P12, DOI 10.1524/itit.46.1.12.26503

[8] Time hierarchies in the Escherichia coli carbohydrate uptake and metabolism [J].

Kremling, A ;

Fischer, S ;

Sauter, T ;

Bettenbrock, K ;

Gilles, ED .

BIOSYSTEMS, 2004, 73 (01) :57-71

[9] The organization of metabolic reaction networks. III. Application for diauxic growth on glucose and lactose [J].

Kremling, A ;

Bettenbrock, K ;

Laube, B ;

Jahreis, K ;

Lengeler, JW ;

Gilles, ED .

METABOLIC ENGINEERING, 2001, 3 (04) :362-379

[10]

KREMLING A, 2005, TOPICS CURRENT GENET, V13

← 1 2 →