Current and future biomarkers in gastric cancer

被引：45
作者：
Abbas, Muhammad [1 ,2 ,3 ]
Faggian, Alessia [4 ]
Sintali, Dahiru Nasiru [5 ]
Khan, Ghulam Jilany [6 ,7 ,8 ]
Naeem, Shagufta [9 ]
Shi, Meiqi [2 ,3 ]
Chen Dingding [1 ]
机构：
[1] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Clin Pharm, Nanjing 211198, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Canc Hosp, Dept Oncol, Jiangsu Canc Hosp, 42 Baiziting, Nanjing 210009, Jiangsu, Peoples R China
[3] Jiangsu Inst Canc Res, 42 Baiziting, Nanjing 210009, Jiangsu, Peoples R China
[4] Azienda ULSS 3 Serenissima, SS Giovanni & Paolo Reg Hosp, Reg Ctr Biomarkers, Dept Clin Pathol & Transfus Med, Campo SS Giovanni & Paolo 6777, I-30122 Venice, VE, Italy
[5] China Pharmaceut Univ, Sch Pharm, Dept Pharm, Nanjing 211198, Jiangsu, Peoples R China
[6] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, Nanjing 210009, Jiangsu, Peoples R China
[7] Univ Cent Punjab, Fac Pharm, Dept Pharmacol & Therapeut, Lahore, Pakistan
[8] Southeast Univ, State Key Lab Bioelect, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China
[9] Ayub Med Coll, Dept Pathol, Abbottabad 22040, Pakistan
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 103卷
关键词：
Gastric cancer; Predictive biomarkers; Treatment; Signaling cascades; Response to treatments; Clinical significance; Emerging markers; GROWTH-FACTOR RECEPTOR; MULTICENTER PHASE-II; C-ERBB-2 PROTEIN EXPRESSION; E-CADHERIN; GENE AMPLIFICATION; MET EXPRESSION; LUNG-CANCER; FACTOR VEGF; C-MET; PROGNOSTIC-SIGNIFICANCE;
D O I：
10.1016/j.biopha.2018.04.178
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Gastric cancer is the fourth most common worldwide cause of cancer-related death. Early gastric cancer has no associated symptoms, for this reason, patients come to the attention of the clinicians only in advanced stages. This paper aims to give a global view on the biomarkers for gastric cancer and the therapy in use. We discuss VEGF family, HER family, E-cadherin, PD-L1, and PD-L2, FGFR, mTOR. Finally, we considered emerging biomarkers as MET, microsatellite instability, and microRNA variations. Furthermore, we have analyzed in depth the chemotherapeutic and adjuvant therapies used in the clinic nowadays, comparing the overall and progression-free survival between them. Identifying and validating diagnostic, prognostic, predictive, and pharmacodynamic biomarkers will be mandatory to the huge impact on patients' outcomes and for improving the efficiency of the drug development process.
引用
收藏
页码：1688 / 1700
页数：13
相关论文
共 211 条
  • [21] Prognostic Implications of Altered Human Epidermal Growth Factor Receptors (HERs) in Gastric Carcinomas: HER2 and HER3 Are Predictors of Poor Outcome
    Begnami, Maria D.
    Fukuda, Emy
    Fregnani, Jose H. T. G.
    Nonogaki, Suely
    Montagnini, Andre L.
    da Costa, Wilson L., Jr.
    Soares, Fernando A.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (22) : 3030 - 3036
  • [22] Genomic variations in non-coding RNAs: Structure, function and regulation
    Bhartiya, Deeksha
    Scaria, Vinod
    [J]. GENOMICS, 2016, 107 (2-3) : 59 - 68
  • [23] Familial Gastric Cancer: Genetics, Diagnosis, and Management
    Blair, Vanessa R.
    [J]. SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2012, 21 (01) : 35 - +
  • [24] Clinical Benefit and Health-Related Quality of Life Assessment in Patients Treated with Cisplatin/S-1 Versus Cisplatin/5-FU: Secondary End Point Results From the First-Line Advanced Gastric Cancer Study (FLAGS)
    Bodoky G.
    Scheulen M.E.
    Rivera F.
    Jassem J.
    Carrato A.
    Moiseyenko V.
    Vynnychenko I.
    Prausová J.
    Van Laethem J.-L.
    Cascinu S.
    Ajani J.A.
    [J]. Journal of Gastrointestinal Cancer, 2015, 46 (2) : 109 - 117
  • [25] Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer
    Carlomagno, Nicola
    Incollingo, Paola
    Tammaro, Vincenzo
    Peluso, Gaia
    Rupealta, Niccolo
    Chiacchio, Gaetano
    Sotelo, Maria Laura Sandoval
    Minieri, Gianluca
    Pisani, Antonio
    Riccio, Eleonora
    Sabbatini, Massimo
    Bracale, Umberto Marcello
    Calogero, Armando
    Dodaro, Concetta Anna
    Santangelo, Michele
    [J]. BIOMED RESEARCH INTERNATIONAL, 2017, 2017
  • [26] Angiogenesis in life, disease and medicine
    Carmeliet, P
    [J]. NATURE, 2005, 438 (7070) : 932 - 936
  • [27] Angiogenesis in cancer and other diseases
    Carmeliet, P
    Jain, RK
    [J]. NATURE, 2000, 407 (6801) : 249 - 257
  • [28] Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening
    Carneiro, F
    Huntsman, DG
    Smyrk, TC
    Owen, DA
    Seruca, R
    Pharoah, P
    Caldas, C
    Sobrinho-Simoes, M
    [J]. JOURNAL OF PATHOLOGY, 2004, 203 (02) : 681 - 687
  • [29] E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions
    Carneiro, Patricia
    Sofia Fernandes, Maria
    Figueiredo, Joana
    Caldeira, Joana
    Carvalho, Joana
    Pinheiro, Hugo
    Leite, Marina
    Melo, Soraia
    Oliveira, Patricia
    Simoes-Correia, Joana
    Jose Oliveira, Maria
    Carneiro, Fatima
    Figueiredo, Ceu
    Paredes, Joana
    Oliveira, Carla
    Seruca, Raquel
    [J]. FEBS LETTERS, 2012, 586 (18): : 2981 - 2989
  • [30] Clinical management of gastroesophageal junction tumors: past and recent evidences for the role of radiotherapy in the multidisciplinary approach
    Cellini, Francesco
    Morganti, Alessio G.
    Di Matteo, Francesco M.
    Mattiucci, Gian Carlo
    Valentini, Vincenzo
    [J]. RADIATION ONCOLOGY, 2014, 9
12345678910