Altered signaling triggered by ligation of the TCR/CD3 receptor in T lymphocytes from patients with systemic lupus erythematosus:: The road from anergy to autoimmunity

被引：3
作者：
Blasini, AM
Rodríguez, MA
机构：
[1] Hosp Univ Caracas, Div Rheumatol, Ctr Nacl Enfermedades Reumat, Caracas, Venezuela
[2] Cent Univ Venezuela, Caracas, Venezuela
[3] Hosp Univ Caracas, Div Rheumatol, Ctr Nacl Enfermedades Reumat, Caracas, Venezuela
来源：
INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2004年 / 23卷 / 3-4期
关键词：
SLE; T cells; signaling; anergy;
D O I：
10.1080/08830180490452594-17
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Some of the signaling phenotypic abnormalities observed in peripheral blood T cells from patients with systemic lupus erythematosus resemble those seen in cells anergized by stimulation through the TCR/CD3 complex, in the absence of costimulatory signals, or by stimulation with altered ligands. The potential association of this "anergic" phenotype and the triggering of autoimmune responses in human lupus is discussed.
引用
收藏
页码：265 / 272
页数：8
相关论文
共 52 条
[21]   Abnormal T cell signal transduction in systemic lupus erythematosus [J].
Kammer, GM ;
Perl, A ;
Richardson, BC ;
Tsokos, GC .
ARTHRITIS AND RHEUMATISM, 2002, 46 (05) :1139-1154
[22]   TYROSINE PHOSPHORYLATION OF A C-SRC-LIKE PROTEIN IS INCREASED IN MEMBRANES OF CD4- CD8- LYMPHOCYTES-T FROM LPR/LPR MICE [J].
KATAGIRI, T ;
TING, JPY ;
DY, R ;
PROKOP, C ;
COHEN, P ;
EARP, HS .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (11) :4914-4922
[23]   Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation [J].
Kersh, EN ;
Shaw, AS ;
Allen, PM .
SCIENCE, 1998, 281 (5376) :572-575
[24]   Dimerization as a regulatory mechanism in signal transduction [J].
Klemm, JD ;
Schreiber, SL ;
Crabtree, GR .
ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :569-592
[25]  
Korb LC, 1999, J IMMUNOL, V162, P6401
[26]   Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: Role of decreased intracellular TNF-alpha [J].
Kovacs, B ;
Vassilopoulos, D ;
Vogelgesang, SA ;
Tsokos, GC .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996, 81 (03) :293-302
[27]  
Leo A, 2002, J CLIN INVEST, V109, P301
[28]   Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4(+) T cells [J].
Li, W ;
Whaley, CD ;
Mondino, A ;
Mueller, DL .
SCIENCE, 1996, 271 (5253) :1272-1276
[29]  
LINKERISRAELI M, 1983, J IMMUNOL, V130, P2651
[30]   Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus - Deficient expression of the T cell receptor zeta chain [J].
Liossis, SNC ;
Ding, XZ ;
Dennis, GJ ;
Tsokos, GC .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (07) :1448-1457
123456