Ganglion cells of the rat retina show osteopontin-like immunoreactivity

被引：27

作者：

Ju, WK ^{[1
]}

Kim, KY ^{[1
]}

Cha, JH ^{[1
]}

Kim, IB ^{[1
]}

Lee, MY ^{[1
]}

Oh, SJ ^{[1
]}

Chung, JW ^{[1
]}

Chun, MH ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Anat, Seoul 137701, South Korea

来源：

BRAIN RESEARCH | 2000年 / 852卷 / 01期

关键词：

osteopontin; ganglion cells; axotomy; retina; rat;

D O I：

10.1016/S0006-8993(99)02140-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Osteopontin (OPN) is a negatively charged, highly acidic glycosylated phosphoprotein that contains an GRGDS amino acid sequence, characteristic of proteins that bind to integrin receptors, thereby playing crucial roles in a number of physiological processes. This study was conducted to examine the expression of OPN in the rat retina by Northern blot analysis, Western blot analysis and immunocytochemistry. The expression of OPN was identified in the retina and OPN-like immunoreactivity was present in a number of ganglion cells. Thus, OPN appears to be important in the retinal homeostasis. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：217 / 220

页数：4

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