Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats

被引：22
作者：
Yao, Hsien-Tsung [1 ]
Hsu, Ya-Ru [1 ]
Lii, Chong-Kuei [1 ,2 ]
Lin, Ai-Hsuan [1 ]
Chang, Keng-Hao [1 ]
Yang, Hui-Ting [1 ]
机构：
[1] China Med Univ, Dept Nutr, Taichung 404, Taiwan
[2] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413, Taiwan
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 70卷
关键词：
Green tea; Black tea; Drug-metabolizing enzymes; Oxidative stress; Rats; PHASE-II ENZYMES; INDUCTION; POLYPHENOLS; LIVER; TRANSFORMATION; GLUTATHIONE; INHIBITION; RECEPTOR; CYSTEINE; INFLAMMATION;
D O I：
10.1016/j.fct.2014.04.043
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The effect of commercially available green tea (GT) and black tea (BT) drinks on drugmetabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory chow diet and GT or BT drink for 5 weeks. Control rats received de-ionized water instead of the tea drinks. Rats received the GT and BT drinks treatment for 5 weeks showed a significant increase in hepatic microsomal cytochrome P450 (CYP) 1A1 and CYP1A2, and a significant decrease in CYP2C, CYP2E1 and CYP3A enzyme activities. Results of immunoblot analyses of enzyme protein contents showed the same trend with enzyme activity. Significant increase in UDP-glucuronosyltransferase activity and reduced glutathione content in liver and lungs were observed in rats treated with both tea drinks. A lower lipid peroxide level in lungs was observed in rats treated with GT drink. Electrophoretic mobility shift assay revealed that both tea drinks decreased pregnane X receptor binding to DNA and increased nuclear factor-erythroid 2 p45-related factor 2 binding to DNA. These results suggest that feeding of both tea drinks to rats modulated DME activities and reduced oxidative stress in liver and lungs. GT drink is more effective on reducing oxidative stress than BT drink. (C) 2014 Elsevier Ltd. All rights reserved.
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收藏
页码：120 / 127
页数：8
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