Nickel-catalyzed N-arylation of amines with arylboronic acids under open air

被引：17

作者：

Ando, Shin ^{[1
]}

Hirota, Yurina ^{[1
]}

Matsunaga, Hirofumi ^{[1
]}

Ishizuka, Tadao ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Life Sci, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 18期

关键词：

NHC; Nickel catalyst; Chan-Lam; C-N coupling; DYNAMIC KINETIC RESOLUTION; HETEROATOM BOND FORMATION; CROSS-COUPLING REACTIONS; C-N; ARYL; COMPLEXES; ETHERS; LIGAND; ESTERS; TRANSMETALATION;

D O I：

10.1016/j.tetlet.2019.04.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, a well-defined, novel NHC-Ni complex was developed and used to catalyze the N-arylation of alkyl- and arylamines with arylboronic acids in a rare version of Chan-Lam coupling. Although the same coupling using copper catalysts has been widely studied, the nickel-catalyzed version is rare and normally requires 10-20 mol% catalyst loading. This novel NHC-Ni complex in combination with 4,4'-dimethyl-2,2'-bipyridine, however, proved to be an effective catalyst that lowered the required catalyst loading to only 2.0 mol%. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1277 / 1280

页数：4

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