Polyprenylated polycyclic acylphloroglucinol: Angiogenesis inhibitor from Garcinia multiflora

被引：14

作者：

Cheng, Lin-Yang ^{[1
]}

Chen, Chun-Lin ^{[2
]}

Kuo, Yueh-Hsiung ^{[3
,4
]}

Chang, Tsung-Hsien ^{[5
]}

Lin, I-Wei ^{[6
]}

Wang, Shih-Wei ^{[6
]}

Chung, Mei-Ing ^{[1
]}

Chen, Jih-Jung ^{[7
,8
]}

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 804, Taiwan

[3] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan

[4] Asia Univ, Dept Biotechnol, Taichung 413, Taiwan

[5] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan

[6] Mackay Med Coll, Dept Med, New Taipei 252, Taiwan

[7] Natl Yang Ming Univ, Fac Pharm, Sch Pharmaceut Sci, Taipei 112, Taiwan

[8] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 10期

关键词：

Garcinia multiflora; Guttiferae; Polyprenylated polycyclic; acylphloroglucinol; Garcimultiflorone K; Angiogenesis inhibitor; DERIVATIVES; XANTHONES; FRUITS; BENZOPHENONES; SUBELLIPTICA;

D O I：

10.1016/j.bmcl.2018.04.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new polyprenylated polycyclic acylphloroglucinol, garcimultiflorone K (1), has been isolated from the stems of Gamma multiflora, together with two known compounds, garcimultiflorone A (2) and garcimultiflorone B (3). The structure of new compound 1 was determined through spectroscopic methods including 1D and 2D NMR and MS analyses. The anti-angiogenic and anti-cancer effects of compounds 1 -3 were evaluated in human endothelial progenitor cells (EPCs) and cancer cells. Of these, garcimultiflorone K (1) displayed the most potent anti-angiogenic property by suppressing cell growth and tube formation of EPCs. Compound 1 also exhibited growth-inhibitory activities against human hepatocellular carcinoma cell line SK-Hep-1 and hormone refractory prostate cancer cell line PC-3 with GI(50) values of 4.3 +/- 1.6 and 6.6 +/- 0.4 mu M, respectively. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1860 / 1863

页数：4

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