Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma

被引:5
作者
Banaszkiewicz, Malgorzata [1 ]
Malyszko, Jolanta [2 ]
Batko, Krzysztof [1 ]
Koc-Zorawska, Ewa [3 ]
Zorawski, Marcin [4 ]
Dumnicka, Paulina [5 ]
Jurczyszyn, Artur [6 ]
Woziwodzka, Karolina [1 ]
Tisonczyk, Joanna [5 ]
Krzanowski, Marcin [1 ]
Malyszko, Jacek [7 ]
Waszczuk-Gajda, Anna [8 ]
Drozdz, Ryszard [5 ]
Kuzniewski, Marek [1 ]
Krzanowska, Katarzyna [1 ]
机构
[1] Jagiellonian Univ, Chair & Dept Nephrol, Med Coll, Krakow, Poland
[2] Med Univ Warsaw, Dept Nephrol Dialysis & Internal Med, Warsaw, Poland
[3] Med Univ Bialystok, Dept Nephrol & Hypertens 2, Dialysis Unit, Bialystok, Poland
[4] Med Univ Bialystok, Dept Clin Med, Bialystok, Poland
[5] Jagiellonian Univ, Dept Med Diagnost, Med Coll, Krakow, Poland
[6] Jagiellonian Univ, Chair & Dept Hematol, Med Coll, Krakow, Poland
[7] Med Univ Bialystok, Dept Nephrol & Transplantol 1, Dialysis Unit, Bialystok, Poland
[8] Med Univ Warsaw, Dept Hematol Oncol & Internal Dis, Warsaw, Poland
关键词
DIFFERENTIATION FACTOR 15; GELATINASE-ASSOCIATED LIPOCALIN; MESENCHYMAL STEM-CELLS; GDF15; ANEMIA; HEPCIDIN; DISEASE; DIAGNOSIS; INJURY;
D O I
10.1155/2020/5657864
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor-beta superfamily, participates in processes associated with myeloma development and its end-organ complications. It plays a significant role in both physiological and abnormal erythropoiesis and regulates iron homeostasis through modulation of hepcidin. It is abnormally secreted in marrow stromal cells of patients with multiple myeloma (MM), which may reflect the tumor microenvironment. We analyzed the associations of serum GDF-15 with clinical characteristics of 73 MM patients (including asymptomatic MM) and the laboratory indices of renal function, anemia, and inflammation. Baseline serum GDF-15 was studied as the predictor of two-year survival. We defined five clinically relevant subgroups of patients (symptomatic MM only, patients with and without remission, patients on chemotherapy, and without treatment). Increased GDF-15 concentrations were associated with more advanced MM stage, anemia, renal impairment (lower glomerular filtration and higher markers of tubular injury), and inflammation. Most of the results were confirmed in the subgroup analysis. Serum cystatin C and urine neutrophil gelatinase-associated lipocalin were associated with GDF-15 independently of other variables. In the studied MM patients, GDF-15 did not significantly predict survival (p=0.06). Our results suggest that serum GDF-15 reflects myeloma burden and shares a relationship with several markers of prognostic significance, as well as major manifestations.
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页数:13
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