Reduced Cerebrospinal Fluid Mitochondrial DNA Is a Biomarker for Early-Stage Parkinson's Disease

被引：109

作者：

Pyle, Angela ^{[1
]}

Brennan, Rebecca ^{[1
]}

Kurzawa-Akanbi, Marzena ^{[1
]}

Yarnall, Alison ^{[2
]}

Thouin, Anais ^{[2
]}

Mollenhauer, Brit ^{[3
]}

Burn, David ^{[2
]}

Chinnery, Patrick F. ^{[1
]}

Hudson, Gavin ^{[1
]}

机构：

[1] Newcastle Univ, Mitochondrial Res Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Univ Goettingen, Inst Neuropathol, Gottingen, Germany

来源：

ANNALS OF NEUROLOGY | 2015年 / 78卷 / 06期

关键词：

MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; COPY NUMBERS; ICICLE-PD; DIAGNOSIS; DYSFUNCTION; DEMENTIA; NEURONS;

D O I：

10.1002/ana.24515

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The identification of cell-free circulating mitochondrial DNA (ccf-mtDNA) in early-stage Alzheimer's disease (AD) raised the possibility that the same neurodegenerative effect could be observed in Parkinson's disease (PD). Here, and for the first time, we investigated the role of ccf-mtDNA in PD, identifying a significant reduction of ccf-mtDNA in PD patient cerebrospinal fluid (CSF) when compared to controls. Our data demonstrates that CSF ccf-mtDNA is not only a powerful biomarker for PD, but, given that the effect is also observed in AD, is likely a biomarker for neurodegeneration.

引用

页码：1000 / 1004

页数：5

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