Hereditary Spastic Paraplegia: Clinical Principles and Genetic Advances

被引：84

作者：

Fink, John K. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Neurol, Ann Arbor, MI USA

[2] Ann Arbor Vet Affairs Med Ctr, Ann Arbor, MI USA

来源：

SEMINARS IN NEUROLOGY | 2014年 / 34卷 / 03期

基金：

美国国家卫生研究院;

关键词：

spastic paraplegia; hereditary; spinal cord; genetic; THIN CORPUS-CALLOSUM; MUTILATING SENSORY NEUROPATHY; PELIZAEUS-MERZBACHER DISEASE; MOTOR-NEURON DISEASE; TROYER-SYNDROME; CEREBRAL-PALSY; PROTEIN COMPLEX; INTELLECTUAL DISABILITY; DEFICIENCY CAUSES; COMPLICATED FORM;

D O I：

10.1055/s-0034-1386767

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hereditary spastic paraplegia (HSP) refers to inherited disorders in which spastic gait is either the only feature or is a major syndrome feature. There are more than 70 genetic types of HSP. Neuropathological studies, albeit limited to only a few genetic types of HSP, have identified axon degeneration involving the distal ends of the corticospinal tracts and fasciculus gracilis fibers. In this review, the author highlights the clinical and genetic features of HSP.

引用

页码：293 / 305

页数：13

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