To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions

被引：160

作者：

Arnold, Kenny

Davies, Bryan

Giles, Richard L.

Grosjean, Christophe

Smith, Gillian E.

Whiting, Andrew

机构：

[1] Univ Durham, Sci Labs, Dept Chem, Durham DH1 3LE, England

[2] GlaxoSmithKline Res & Dev Ltd, Stevenage SG1 2NY, Herts, England

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 7-8期

关键词：

amines; bifunctional catalysis; boronate catalysis; carboxylic acids; direct amide formation; green catalysis;

D O I：

10.1002/adsc.200606018

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Kinetic studies show that the direct formation of amides from amines and carboxylic acids without catalyst does occur under relatively low temperature conditions, but is highly substrate dependent. Boric and boronic acid-based catalysts improve the reaction, especially for less reactive acids, and initial results indicate that bifunctional catalysts show even Greater potential.

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收藏

页码：813 / 820

页数：8

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