Regulating microbiome manipulation

被引：5

作者：

Aagaard, Kjersti ^{[1
,2
,3
,4
]}

Hohmann, Elizabeth ^{[5
]}

机构：

[1] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Cell & Mol Biol, Houston, TX 77030 USA

[4] Texas Childrens Hosp, Houston, TX 77030 USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Div Infect Dis, Boston, MA 02115 USA

来源：

NATURE MEDICINE | 2019年 / 25卷 / 06期

关键词：

D O I：

10.1038/s41591-019-0451-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A crucial consideration for the clinical application of any burgeoning science is when the understanding of that field can be implemented without the risk of unforeseen harm. In our opinion, the need for caution is particularly urgent with respect to increasingly prevalent applications of microbiome science to medicine.

引用

页码：874 / 876

页数：4

共 12 条

[1] The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters [J].

Aagaard, Kjersti ;

Petrosino, Joseph ;

Keitel, Wendy ;

Watson, Mark ;

Katancik, James ;

Garcia, Nathalia ;

Patel, Shital ;

Cutting, Mary ;

Madden, Tessa ;

Hamilton, Holli ;

Harris, Emily ;

Gevers, Dirk ;

Simone, Gina ;

McInnes, Pamela ;

Versalovic, James .

FASEB JOURNAL, 2013, 27 (03) :1012-1022

[2]

[Anonymous], BACT RISK CONTR STRA

[3] Fecal Microbiota-based Therapeutics for Recurrent Clostridium difficile Infection, Ulcerative Colitis and Obesity [J].

Carlucci, Christian ;

Petrof, Elaine O. ;

Allen-Vercoe, Emma .

EBIOMEDICINE, 2016, 13 :37-45

[4] Diagnosis and Treatment of Clostridium difficile Infection [J].

Gupta, Arjun ;

Cifu, Adam S. ;

Khanna, Sahil .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 320 (10) :1031-1032

[5] Improving regulation of microbiota transplants [J].

Hoffmann, Diane ;

Palumbo, Francis ;

Ravel, Jacques ;

Roghmann, Mary-Claire ;

Rowthorn, Virginia ;

von Rosenvinge, Erik .

SCIENCE, 2017, 358 (6369) :1390-1391

[6] Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials0 [J].

Kristensen, Nadja B. ;

Bryrup, Thomas ;

Allin, Kristine H. ;

Nielsen, Trine ;

Hansen, Tue H. ;

Pedersen, Oluf .

GENOME MEDICINE, 2016, 8

[7] Ensuring the safe and effective FDA regulation of fecal microbiota transplantation [J].

Sachs, Rachel E. ;

Edelstein, Carolyn A. .

JOURNAL OF LAW AND THE BIOSCIENCES, 2015, 2 (02) :396-415

[8] The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists [J].

Thomas, Sunil ;

Izard, Jacques ;

Walsh, Emily ;

Batich, Kristen ;

Chongsathidkiet, Pakawat ;

Clarke, Gerard ;

Sela, David A. ;

Muller, Alexander J. ;

Mullin, James M. ;

Albert, Korin ;

Gilligan, John P. ;

DiGuilio, Katherine ;

Dilbarova, Rima ;

Alexander, Walker ;

Prendergast, George C. .

CANCER RESEARCH, 2017, 77 (08) :1783-1812

[9]

U.S. Food & Drug Administration, 2016, ENF POL REG INV NEW

[10]

van Nood E, 2013, NEW ENGL J MED, V368, P2145, DOI [10.1056/NEJMoa1205037, 10.1056/NEJMc1303919]

← 1 2 →