The CALM and CALM/AF10 interactor CATS is a marker for proliferation

被引：38
作者：
Archangelo, Leticia Froehlich [1 ,2 ,6 ]
Greif, Philipp A. [1 ,2 ]
Hoelzel, Michael [3 ]
Harasim, Thomas [3 ]
Kremmer, Elisabeth [4 ]
Przemeck, Gerhard K. H. [5 ]
Eick, Dirk [4 ]
Deshpande, Aniruddha Jayant [1 ,2 ]
Buske, Christian [1 ,2 ]
de Angelis, Martin Hrabe [5 ]
Olalla Saad, Sara Teresinha [6 ]
Bohlander, Stefan K. [1 ,2 ]
机构：
[1] Univ Munich, Hosp Grosshadern, Dept Med 3, D-81377 Munich, Germany
[2] German Res Ctr Environm Hlth, Clin Cooperat Grp Leukemia, D-81377 Munich, Germany
[3] German Res Ctr Environm Hlth, Inst Clin Mol Biol & Tumor Genet, D-81377 Munich, Germany
[4] German Res Ctr Environm Hlth, Inst Mol Immunol, D-81377 Munich, Germany
[5] German Res Ctr Environm Hlth, Inst Expt Genet, D-85764 Munich, Germany
[6] Univ Estadual Campinas, UNICAMP, Hematol & Hemotherapy Ctr, BR-13083970 Campinas, SP, Brazil
来源：
MOLECULAR ONCOLOGY | 2008年 / 2卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
CALM/AF10; Leukemia; Nucleolus; Proliferation; CATS;
D O I：
10.1016/j.molonc.2008.08.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：356 / 367
页数：12
相关论文
共 56 条
[1]   The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10 [J].
Archangelo, L. Froehlich ;
Glaeser, J. ;
Krause, A. ;
Bohlander, S. K. .
ONCOGENE, 2006, 25 (29) :4099-4109
[2]   Impact of TCR status and genotype on outcome in adult T-cell acute lymphoblastic leukemia: a LALA-94 study [J].
Asnafi, V ;
Buzyn, A ;
Thomas, X ;
Huguet, F ;
Vey, N ;
Boiron, JM ;
Reman, O ;
Cayuela, JM ;
Lheritier, V ;
Vernant, JP ;
Fiere, D ;
Macintyre, E ;
Dombret, H .
BLOOD, 2005, 105 (08) :3072-3078
[3]   Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy [J].
Asnafi, V ;
Beldjord, K ;
Libura, M ;
Villarese, P ;
Millien, C ;
Ballerini, P ;
Kuhlein, E ;
Lafage-Pochitaloff, M ;
Delabesse, E ;
Bernard, O ;
Macintyre, E .
BLOOD, 2004, 104 (13) :4173-4180
[4]   CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCR-γδ lineage [J].
Asnafi, V ;
Radford-Weiss, I ;
Dastugue, N ;
Bayle, C ;
Leboeuf, D ;
Charrin, C ;
Garand, R ;
Lafage-Pochitaloff, M ;
Delabesse, E ;
Buzyn, A ;
Troussard, X ;
Macintyre, E .
BLOOD, 2003, 102 (03) :1000-1006
[5]   Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins [J].
Ayton, PM ;
Cleary, ML .
ONCOGENE, 2001, 20 (40) :5695-5707
[6]   Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients [J].
Bohlander, SK ;
Muschinsky, V ;
Schrader, K ;
Siebert, R ;
Schlegelberger, B ;
Harder, L ;
Schemmel, V ;
Fonatsch, C ;
Ludwig, WD ;
Hiddemann, W ;
Dreyling, MH .
LEUKEMIA, 2000, 14 (01) :93-99
[7]   Identification and molecular characterization of CALM/AF10 fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia [J].
Carlson, KM ;
Vignon, C ;
Bohlander, S ;
Martinez-Climent, JA ;
Le Beau, MM ;
Rowley, JD .
LEUKEMIA, 2000, 14 (01) :100-104
[8]  
CAUDELL D, 2007, ROLE CALM AF10 GENE
[9]   Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice [J].
Caudell, David ;
Zhang, Zhenhua ;
Chung, Yang Jo ;
Aplan, Peter D. .
CANCER RESEARCH, 2007, 67 (17) :8022-8031
[10]  
Chao MM, 2005, BLOOD, V106, p696A
123456