Evaluation of absorbed dose in Gadolinium neutron capture therapy

被引：4

作者：

Abdullaeva, Gayane ^{[1
]}

Djuraeva, Gulnara ^{[1
]}

Kim, Andrey ^{[1
]}

Koblik, Yuriy ^{[1
]}

Kulabdullaev, Gairatulla ^{[1
]}

Rakhmonov, Turdimukhammad ^{[1
]}

Saytjanov, Shavkat ^{[1
]}

机构：

[1] Inst Nucl Phys Uz AS, Tashkent, Uzbekistan

来源：

OPEN PHYSICS | 2015年 / 13卷 / 01期

关键词：

GdNCT; Magnevist; absorbed dose; kerma; amount of gadolinium; COMPLEX; AGENT;

D O I：

10.1515/phys-2015-0022

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Gadolinium neutron capture therapy (GdNCT) is used for treatment of radioresistant malignant tumors. The absorbed dose in GdNCT can be divided into four primary dose components: thermal neutron, fast neutron, photon and natural gadolinium doses. The most significant is the dose created by natural gadolinium. The amount of gadolinium at the irradiated region is changeable and depends on the gadolinium delivery agent and on the structure of the location where the agent is injected. To define the time dependence of the gadolinium concentration rho(t) in the irradiated region the pharmacokinetics of gadolinium delivery agent (Magnevist) was studied at intratumoral injection in mice and intramuscular injection in rats. A polynomial approximation was applied to the experimental data and the influence of rho(t) on the relative change of the absorbed dose of gadolinium was studied.

引用

页码：183 / 187

页数：5

共 19 条

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