Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of colorectal cancer

被引：181

作者：

Ge, Penglei ^{[1
]}

Wang, Weiwei ^{[2
]}

Li, Lin ^{[1
]}

Zhang, Gong ^{[1
]}

Gao, Zhiqiang ^{[1
]}

Tang, Zhe ^{[1
]}

Dang, Xiaowei ^{[1
]}

Wu, Yang ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Hepatobiliary & Pancreat Surg, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou, Henan, Peoples R China

[2] Zhengzhou Univ, Dept Pathol, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou, Henan, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 118卷

关键词：

Immune cell; Immune-related genes; Immunotherapy; Colorectal cancer; Tumor microenvironment; NEUROTENSIN; PROGRESSION; EXPRESSION; RECEPTOR; GROWTH; STC2; MACROPHAGES; EPIREGULIN; ACTIVATION; PROMOTES;

D O I：

10.1016/j.biopha.2019.109228

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Purpose: tumor-infiltrating immune cells are highly relevant to the progression and prognosis of colorectal cancer (CRC). The aim of this study is to explore the immune cells and immune-related gene expression in tumor microenvironment of CRC. Methods: CIBERSORT, a deconvolution algorithm, was used to analyze the infiltration of 22 immune cell types in the tumor microenvironment and immune-related gene expression in 404 CRC and 40 adjacent non-tumorous tissues. Results: a wide heterogeneity of immune cells among different paired tissues and in tumor stages was uncovered. M0 macrophages, M1 macrophages and CD4 memory activated T cells were infiltrated significantly more in CRC compared with normal tissues in both TCGA and GEO cohorts. CRC with T1-2 tumor stage showed increased CD4 memory activated T cells compared with T3-4 tumors. M0 macrophages were the highest in stage N1 tumors. Significant immune-related genes were identified to build prognostic models by Cox regression analysis. The concordance index of the prognostic model for TNM stage I-II was 0.69, and 0.71 for stage III-IV. The AUC values for 1-, 3-, and 5-year survivals were 0.674, 0.773, 0.812 for TNM stage I-II, respectively, and 0.764, 0.782, 0.803 for stage III-IV respectively. Conclusion: these results could assist clinicians in selecting targets for immunotherapies and individualize treatment strategies for patients with CRC.

引用

页数：10

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