Salient features of medical nanoparticles in biological fluids from an analytical ultracentrifuge

被引:8
作者
Cinar, Gizem [1 ,2 ]
Englert, Christoph [3 ]
Schubert, Ulrich S. [1 ,2 ]
Nischang, Ivo [1 ,2 ]
机构
[1] Friedrich Schiller Univ Jena, Lab Organ & Macromol Chem IOMC, Humboldtstr 10, D-07743 Jena, Germany
[2] Friedrich Schiller Univ Jena, Jena Ctr Soft Matter JCSM, Philosophenweg 7, D-07743 Jena, Germany
[3] SmartDyeLivery GmbH, D-07743 Jena, Germany
关键词
NANOMEDICINE; SCATTERING; DELIVERY;
D O I
10.1039/d0nr06153k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
From the perspective of future translation, medical, biodegradable nanoparticles (NPs) have been investigated using an analytical ultracentrifuge in fluids of various complexity, including human serum, in the temperature range of 6 to 40 degrees C, and timescales relevant for a nanomedical targeting and clearance application. These studies provided salient insights into the integrity and degradation aspects of the NPs, imposed by varying solution environmental conditions. This was enabled by selective monitoring of the targeting dye moiety, cell-specifically directing the NPs to the desired location of interest, i.e. considering a future translative in vivo application. Our study provides experimental insights that are believed to be of key importance to gauge the feasibility of such translative applications in terms of (i) compatibility with patient sera, (ii) timescales of targeting success, and (iii) timescales of desired erosion enabling clearance from the target. All such aspects are provided a priori any in vivo implementation.
引用
收藏
页码:22462 / 22466
页数:5
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