Modulating T-cell homeostasis with IL-7: preclinical and clinical studies

被引：78
作者：
Capitini, C. M. [1 ]
Chisti, A. A. [1 ]
Mackall, C. L. [1 ]
机构：
[1] NCI, Immunol Sect, Pediat Oncol Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF INTERNAL MEDICINE | 2009年 / 266卷 / 02期
关键词：
cytokines; immunotherapy; lymphopenia; T cell; BONE-MARROW-TRANSPLANTATION; INTERLEUKIN-7; RECEPTOR-ALPHA; IMMUNODEFICIENCY-VIRUS TYPE-1; TUMOR-NECROSIS-FACTOR; IN-VIVO; IMMUNE RECONSTITUTION; PERIPHERAL-BLOOD; POTENTIAL ROLE; MURINE IL-7; EXPRESSION;
D O I：
10.1111/j.1365-2796.2009.02085.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.
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收藏
页码：141 / 153
页数：13
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