Regioselective alkylations of optically active 4,5-dihydro-1,2,4-triazin-6(1H)-ones

被引：3

作者：

Sanière, L ^{[1
]}

Schmitt, M ^{[1
]}

Bourguignon, JJ ^{[1
]}

机构：

[1] Fac Pharm, Lab Pharmacochim Commun Cellulaire, UMR 7081, CNRS, F-67400 Illkirch, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(99)02162-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regiocontrolled alkylations of chiral 4,5-dihydrotriazin-6-ones using sodium hydride in DMF are reported. By this approach different N1-alkyl, N1,N4-dialkyl and N4-alkyl dihydrotriazinones could be obtained in good yields with conservation of their optical activity. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：671 / 674

页数：4

共 8 条

[1] STUDIES ON AMINO-ACIDS AND PEPTIDES .4. 1,2,4-TRIAZINES FROM THIOACYLATED AMINO-ACID ESTERS [J].

ANDERSEN, TP ;

GHATTAS, ABAG ;

LAWESSON, SO .

TETRAHEDRON, 1983, 39 (20) :3419-3427

[2]

CHAYER S, UNPUB

[3] Regiospecific syntheses of the monomethylated 3-phenyldihydro-1,2,4-triazin-6(1H)-ones [J].

Collins, DJ ;

Hughes, TC ;

Johnson, WM .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1996, 49 (04) :463-468

[4]

ELABADELAH MM, 1991, HETEROCYCLES, V32, P1879

[5]

FAIRLIE DP, 1995, CURR MED CHEM, V2, P654

[6]

KAJI K, 1970, CHEM PHARM BULL, V18, P147

[7]

NEUNHOEFFER H, 1992, LIEBIGS ANN CHEM, P1271

[8]

SMODIS J, 1990, HETEROCYCLES, V30, P393

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