The role of retinal Muller cells in diabetic retinopathy and related therapeutic advances

被引：28
作者：
Yang, Shuo [1 ]
Qi, Shounan [1 ]
Wang, Chenguang [1 ]
机构：
[1] Second Hosp Jilin Univ, Dept Ophthalmol, Changchun, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷
关键词：
diabetic retinopathy; retinal Muller cells; neurodegeneration; inflammation; treatment; GLIAL-CELLS; EXPRESSION; CD40; NEURODEGENERATION; COMMUNICATION; DYSFUNCTION; ACTIVATION; RECEPTORS; CHANNELS; VEGF;
D O I：
10.3389/fcell.2022.1047487
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Diabetic retinopathy (DR) is a significant complication of diabetes. During the pathogenesis of retinal microangiopathy and neuronopathy, activated retinal Muller cells (RMCs) undergo morphological and structural changes such as increased expression of glial fibrillary acidic protein, disturbance of potassium and water transport regulation, and onset of production of a large number of inflammatory and vascular growth factors as well as chemokines. Evidently, activated RMCs are necessary for the pathogenesis of DR; therefore, exploring the role of RMCs in DR may provide a new target for the treatment thereof. This article reviews the mechanism of RMCs involvement in DR and the progress in related treatments.
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页数：12
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