Concomitant white matter (WM) brain pathology is often present in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Cognitive effects of WM pathology on cognition in normal and pathological aging have been studied, but very little is known about possible group-specific effects in old age, MCI and AD. The purpose of the current study was to examine the relationship between WM pathology and cognitive functioning in four cognitive domains in old age, MCI and AD. The study utilized multi-domain neuropsychological data and visually rated MRI imaging data from a sample of 56 healthy older adults, 40 patients with MCI and 52 patients with AD (n = 148). After controlling for age and education, main effects of frontal WM pathology (especially in the left hemisphere) were found for cognitive performances in two domains, whereas a main effect of parieto-occipital WM pathology was only found for processing speed. In addition, with regard to processing speed, an interaction between group and WM changes was found: Patients with AD that had moderate or severe left frontal WM pathology were considerably slower than patients with AD that had milder cerebrovascular pathology. Frontal WM pathology, especially in the left hemisphere, seems to affect cognitive functions in many domains in all three groups. The results of the study increase our knowledge of cognitive repercussions stemming from frontal and/or parieto-occipital WM pathology in AD. Clinicians should be aware that patients with AD with prominent frontal cerebrovascular pathology can have considerably slowed cognitive processing.
机构:
Taipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
Natl Yang Ming Univ, Sch Med, Dept Neurol, Taipei 112, Taiwan
Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
Wang, Pei-Ning
Chou, Kun-Hsien
论文数: 0引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Neurosci, Taipei 112, Taiwan
Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
Chou, Kun-Hsien
Lirng, Jiing-Feng
论文数: 0引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Sch Med, Dept Radiol, Taipei 112, Taiwan
Taipei Vet Gen Hosp, Dept Radiol, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
Lirng, Jiing-Feng
Lin, Ker-Neng
论文数: 0引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Sch Med, Dept Neurol, Taipei 112, Taiwan
Fu Jen Catholic Univ, Dept Psychol, Taipei Cty, TaiwanTaipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
Lin, Ker-Neng
Chen, Wei-Ta
论文数: 0引用数: 0
h-index: 0
机构:
Taipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
Natl Yang Ming Univ, Sch Med, Dept Neurol, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
Chen, Wei-Ta
Lin, Ching-Po
论文数: 0引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Neurosci, Taipei 112, Taiwan
Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
机构:
North Sichuan Med Coll, Inst Rehabil & Imaging Brain Funct, Dept CT MRI, Clin Med Coll 2, Nanchong 637000, Peoples R China
Southwest Med Univ, Dept Med Imaging, Luzhou 646000, Luzhou, Peoples R ChinaNorth Sichuan Med Coll, Inst Rehabil & Imaging Brain Funct, Dept CT MRI, Clin Med Coll 2, Nanchong 637000, Peoples R China
Qin, Linzi
Guo, Zhiwei
论文数: 0引用数: 0
h-index: 0
机构:
North Sichuan Med Coll, Inst Rehabil & Imaging Brain Funct, Dept CT MRI, Clin Med Coll 2, Nanchong 637000, Peoples R ChinaNorth Sichuan Med Coll, Inst Rehabil & Imaging Brain Funct, Dept CT MRI, Clin Med Coll 2, Nanchong 637000, Peoples R China
Guo, Zhiwei
McClure, Morgan A.
论文数: 0引用数: 0
h-index: 0
机构:
North Sichuan Med Coll, Inst Rehabil & Imaging Brain Funct, Dept CT MRI, Clin Med Coll 2, Nanchong 637000, Peoples R ChinaNorth Sichuan Med Coll, Inst Rehabil & Imaging Brain Funct, Dept CT MRI, Clin Med Coll 2, Nanchong 637000, Peoples R China
McClure, Morgan A.
Mu, Qiwen
论文数: 0引用数: 0
h-index: 0
机构:
North Sichuan Med Coll, Inst Rehabil & Imaging Brain Funct, Dept CT MRI, Clin Med Coll 2, Nanchong 637000, Peoples R China
Southwest Med Univ, Dept Med Imaging, Luzhou 646000, Luzhou, Peoples R China
Peking Univ Third Hosp, Dept Radiol, Beijing 100191, Peoples R ChinaNorth Sichuan Med Coll, Inst Rehabil & Imaging Brain Funct, Dept CT MRI, Clin Med Coll 2, Nanchong 637000, Peoples R China
机构:
Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Natl Engn Res Ctr Healthcare Devices, Guangzhou, Guangdong, Peoples R China
Minist Civil Affairs, Key Lab Neuroinformat & Rehabil Engn, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
He, Fangmei
Zhang, Yuchen
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Dept Oncol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Zhang, Yuchen
Wu, Xiaofeng
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Natl Engn Res Ctr Healthcare Devices, Guangzhou, Guangdong, Peoples R China
Minist Civil Affairs, Key Lab Neuroinformat & Rehabil Engn, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Wu, Xiaofeng
Li, Youjun
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Natl Engn Res Ctr Healthcare Devices, Guangzhou, Guangdong, Peoples R China
Minist Civil Affairs, Key Lab Neuroinformat & Rehabil Engn, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Li, Youjun
Zhao, Jie
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Natl Engn Res Ctr Healthcare Devices, Guangzhou, Guangdong, Peoples R China
Minist Civil Affairs, Key Lab Neuroinformat & Rehabil Engn, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Zhao, Jie
Fang, Peng
论文数: 0引用数: 0
h-index: 0
机构:
Air Force Med Univ, Dept Mil Med Psychol, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Fang, Peng
Fan, Liming
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Natl Engn Res Ctr Healthcare Devices, Guangzhou, Guangdong, Peoples R China
Minist Civil Affairs, Key Lab Neuroinformat & Rehabil Engn, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Fan, Liming
Li, Chenxi
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Natl Engn Res Ctr Healthcare Devices, Guangzhou, Guangdong, Peoples R China
Minist Civil Affairs, Key Lab Neuroinformat & Rehabil Engn, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Li, Chenxi
Liu, Tian
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Natl Engn Res Ctr Healthcare Devices, Guangzhou, Guangdong, Peoples R China
Minist Civil Affairs, Key Lab Neuroinformat & Rehabil Engn, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Liu, Tian
Wang, Jue
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
Natl Engn Res Ctr Healthcare Devices, Guangzhou, Guangdong, Peoples R China
Minist Civil Affairs, Key Lab Neuroinformat & Rehabil Engn, Xian, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Hlth & Rehabil Sci, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China
机构:
Univ Southern Calif, Dept Neurol, Los Angeles, CA 90007 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Petkus, Andrew J.
Resnick, Susan M.
论文数: 0引用数: 0
h-index: 0
机构:
NIA, Lab Behav Neurosci, Baltimore, MD 21224 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Resnick, Susan M.
Rapp, Stephen R.
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Psychiat & Behav Med, Winston Salem, NC 27101 USA
Wake Forest Sch Med, Dept Social Sci & Hlth Policy, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Rapp, Stephen R.
Espeland, Mark A.
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Biostat Sci, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Espeland, Mark A.
Gatz, Margaret
论文数: 0引用数: 0
h-index: 0
机构:
Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90007 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Gatz, Margaret
Widaman, Keith F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Riverside, Grad Sch Educ, Riverside, CA 92521 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Widaman, Keith F.
Wang, Xinhui
论文数: 0引用数: 0
h-index: 0
机构:
Univ Southern Calif, Dept Neurol, Los Angeles, CA 90007 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Wang, Xinhui
Younan, Diana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Younan, Diana
Casanova, Ramon
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Biostat Sci, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Casanova, Ramon
Chui, Helena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Southern Calif, Dept Neurol, Los Angeles, CA 90007 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Chui, Helena
Barnard, Ryan T.
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Biostat Sci, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Barnard, Ryan T.
Gaussoin, Sarah
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Biostat Sci, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Gaussoin, Sarah
Goveas, Joseph S.
论文数: 0引用数: 0
h-index: 0
机构:
Med Coll Wisconsin, Dept Psychiat, Tosa Hlth Ctr, Milwaukee, WI 53226 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Goveas, Joseph S.
Hayden, Kathleen M.
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Social Sci & Hlth Policy, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Hayden, Kathleen M.
Henderson, Victor W.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA
Stanford Univ, Dept Neurol & Neurol Sci, 259 Campus Dr, Stanford, CA 94305 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Henderson, Victor W.
Sachs, Bonnie C.
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Social Sci & Hlth Policy, Med Ctr Blvd, Winston Salem, NC 27101 USA
Wake Forest Sch Med, Dept Neurol, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Sachs, Bonnie C.
Saldana, Santiago
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Social Sci & Hlth Policy, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Saldana, Santiago
Shadyab, Aladdin H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Shadyab, Aladdin H.
Shumaker, Sally A.
论文数: 0引用数: 0
h-index: 0
机构:
Wake Forest Sch Med, Dept Neurol, Med Ctr Blvd, Winston Salem, NC 27101 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Shumaker, Sally A.
Chen, Jiu-Chiuan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA
Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USAUniv Southern Calif, Dept Neurol, Los Angeles, CA 90007 USA