Fetal growth restriction and methylation of growth-related genes in the placenta

被引：41

作者：

Xiao, Xirong ^{[1
]}

Zhao, Yan ^{[2
]}

Jin, Rong ^{[3
]}

Chen, Jiao ^{[2
]}

Wang, Xiu ^{[2
]}

Baccarelli, Andrea ^{[4
]}

Zhang, Yunhui ^{[2
]}

机构：

[1] Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200032, Peoples R China

[2] Fudan Univ, Sch Publ Hlth, Dept Environm Hlth, Shanghai 200032, Peoples R China

[3] China Welf Inst, Int Peace Matern & Child Hlth Hosp, Shanghai 200032, Peoples R China

[4] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

来源：

EPIGENOMICS | 2016年 / 8卷 / 01期

基金：

中国国家自然科学基金;

关键词：

birth weight; case-control study; DNA methylation; fetal growth restriction; placenta; ARYL-HYDROCARBON RECEPTOR; DNA METHYLATION; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID-RECEPTOR; IMPRINTED GENES; BIRTH-WEIGHT; IN-UTERO; EXPOSURE; PROMOTER; NEWBORNS;

D O I：

10.2217/epi.15.101

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To examine the associations between fetal growth restriction (FGR) and DNA methylation of six growth-related genes in human placenta. Materials & methods: A total of 181 mother-newborn pairs (80 FGR cases and 101 controls) were enrolled in this case-control study. Placental DNA methylation was measured by bisulfite pyrosequencing. Results: DNA methylation levels of IGF2 and AHRR were positively associated with newborn birth weight and Quetelet's index, while DNA methylation levels of HSD11B2 and WNT2 were negatively associated with those fetal growth indicators. In addition, significantly elevated odds of FGR birth were associated with increasing DNA methylation of HSD11B2 and WNT2, and decreasing DNA methylation of IGF2. Conclusion: Our findings demonstrated that placental DNA methylation levels of IGF2, AHRR, HSD11B2 and WNT2 were associated with measures of fetal growth.

引用

页码：33 / 42

页数：10

共 50 条

[1] Third trimester phthalate exposure is associated with DNA methylation of growth-related genes in human placenta
Zhao, Yan
Chen, Jiao
Wang, Xiu
Song, Qi
Xu, Hui-Hui
Zhang, Yun-Hui
SCIENTIFIC REPORTS, 2016, 6
[2] Third trimester phthalate exposure is associated with DNA methylation of growth-related genes in human placenta
Yan Zhao
Jiao Chen
Xiu Wang
Qi Song
Hui-Hui Xu
Yun-Hui Zhang
Scientific Reports, 6
[3] Placenta and fetal growth restriction
Salafia, Carolyn M.
Charles, Adrian K.
Maas, Elizabeth M.
CLINICAL OBSTETRICS AND GYNECOLOGY, 2006, 49 (02): : 236 - 256
[4] EXPRESSION OF GROWTH-RELATED GENES IN HUMAN FETAL KIDNEY
GOODYER, PR
MULLIGAN, L
GOODYER, CG
AMERICAN JOURNAL OF KIDNEY DISEASES, 1991, 17 (06) : 608 - 610
[5] Diagnostic accuracy of fetal growth charts for placenta-related fetal growth restriction
Melamed, Nir
Hiersch, Liran
Aviram, Amir
Mei-Dan, Elad
Keating, Sarah
Kingdom, John C.
PLACENTA, 2021, 105 : 70 - 77
[6] Fetal growth restriction as the disease of the placenta
Gerecz, Balazs
Belics, Zoran
Gizella, Molnar
Hupuczi, Petronella
ORVOSI HETILAP, 2025, 166 (09) : 331 - 340
[7] Microscopic lesions of placenta and Doppler velocimetry related to fetal growth restriction
Vedmedovska, Natalija
Rezeberga, Dace
Teibe, Uldis
Melderis, Ivars
Donders, Gilbert G. G.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2011, 284 (05) : 1087 - 1093
[8] Microscopic lesions of placenta and Doppler velocimetry related to fetal growth restriction
Natalija Vedmedovska
Dace Rezeberga
Uldis Teibe
Ivars Melderis
Gilbert G. G. Donders
Archives of Gynecology and Obstetrics, 2011, 284 : 1087 - 1093
[9] MECHANISM OF FETAL GROWTH RESTRICTION IN PLACENTA MALARIA
Dimasuay, Kris Genelyn
Rosario, Fredrick
Glazier, Jocelyn
Beeson, James
Rogerson, Stephen
Jansson, Thomas
Boeuf, Philippe
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2017, 95 (05): : 219 - 219
[10] ROLE OF ANGIOGENESIS-RELATED GENES IN FETAL GROWTH RESTRICTION
Kinzler, Wendy
Kizhner, Oskar
Peltier, Morgan
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2008, 199 (06) : S122 - S122

← 1 2 3 4 5 →