miR-27b inhibits gastric cancer metastasis by targeting NR2F2

被引：49

作者：

Feng, Qingzhao ^{[1
]}

Wu, Xionglin ^{[5
]}

Li, Fuchao ^{[2
]}

Ning, Beibei ^{[4
]}

Lu, Xiaofeng ^{[1
]}

Zhang, Yin ^{[1
]}

Pan, Ying ^{[3
]}

Guan, Wenxian ^{[1
]}

机构：

[1] Nanjing Univ, Affiliated Drum Tower Hosp, Sch Med, Dept Gen Surg, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Univ, Affiliated Drum Tower Hosp, Sch Med, Dept Gerontol, Nanjing 210008, Jiangsu, Peoples R China

[3] Nanjing Univ, Affiliated Drum Tower Hosp, Sch Med, Dept Orthopaed, Nanjing 210008, Jiangsu, Peoples R China

[4] Zhejiang Univ, Sch Med, Childrens Hosp, Hangzhou 310003, Zhejiang, Peoples R China

[5] Wenzhou Med Univ, Yiwu Affiliated Hosp, Dept Emergency, Yiwu 322000, Peoples R China

来源：

PROTEIN & CELL | 2017年 / 8卷 / 02期

关键词：

miR-27b; NR2F2; gastric cancer; tumor metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; EXPRESSION; GROWTH; CELLS; SURVIVAL; INVASION; PATHWAY; MIRNAS;

D O I：

10.1007/s13238-016-0340-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Increasing attention is focused on the down-regulation of miRNAs in cancer process. Nuclear receptor subfamily 2 (NR2F2, also known as COUP-TFII) is involved in the development of many types of cancers, but its role in gastric cancer remains elusive. In this experiment, oncomine and Kaplan-meier database revealed that NR2F2 was up-regulated in gastric cancer and that the high NR2F2 expression contributed to poor survival. MicroRNA-27b was targeted and down-regulated by NR2F2 in human gastric cancer tissues and cells. The ectopic expression of miR-27b inhibited gastric cancer cell proliferation and tumor growth in vitro and in vivo. Assays suggested that the overexpression of miR-27b could promote MGC-803 cells' migration and invasion and retard their metastasis to the liver. In addition, down-regulation of miR-27b enhanced GES-1 cells' proliferation and metastasis in vitro. These findings reveal that miR-27b is a tumor suppressor in gastric cancer and a biomarker for improving patients' survival.

引用

页码：114 / 122

页数：9

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