Skin and Plasma Autofluorescence During Hemodialysis: A Pilot Study

被引：14

作者：

Graaff, Reindert ^{[1
]}

Arsov, Stefan ^{[2
]}

Ramsauer, Bernd ^{[6
]}

Koetsier, Marten ^{[2
]}

Sundvall, Nils ^{[6
]}

Engels, Gerwin E. ^{[5
]}

Sikole, Aleksandar ^{[3
]}

Lundberg, Lennart ^{[6
]}

Rakhorst, Gerhard ^{[4
]}

Stegmayr, Bernd ^{[6
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept UMC Staff, Groningen, Netherlands

[2] Univ Groningen, Dept Biomed Engn, Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Groningen, Netherlands

[5] HaemoScan, Groningen, Netherlands

[6] Umea Univ, Dept Publ Hlth & Med, Umea, Sweden

来源：

ARTIFICIAL ORGANS | 2014年 / 38卷 / 06期

关键词：

Hemodialysis; Skin autofluorescence; Plasma autofluorescence; Advanced glycation end products; GLYCATION END-PRODUCTS; CHRONIC KIDNEY-DISEASE; PREDICTS MORTALITY; RISK-FACTORS; PROTEIN; COMPLICATIONS; ACCUMULATION; ENDPRODUCTS; STRESS; MARKER;

D O I：

10.1111/aor.12205

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Skin autofluorescence (AF) is related to the accumulation of advanced glycation end products (AGEs) and is one of the strongest prognostic markers of mortality in hemodialysis (HD) patients. The aim of this pilot study was to investigate whether changes in skin AF appear after a single HD session and if they might be related to changes in plasma AF. Skin and plasma AF were measured before and after HD in 35 patients on maintenance HD therapy (nine women and 26 men, median age 68 years, range 33-83). Median dialysis time was 4h (range 3-5.5). Skin AF was measured noninvasively with an AGE Reader, and plasma AF was measured before and after HD at 460nm after excitation at 370nm. The HD patients had on average a 65% higher skin AF value than age-matched healthy persons (P<0.001). Plasma AF was reduced by 14% (P<0.001), whereas skin AF was not changed after a single HD treatment. No significant influence of the reduced plasma AF on skin AF levels was found. This suggests that the measurement of skin AF can be performed during the whole dialysis period and is not directly influenced by the changes in plasma AF during HD.

引用

页码：515 / 518

页数：4

共 19 条

[1] Increase in Skin Autofluorescence and Release of Heart-Type Fatty Acid Binding Protein in Plasma Predicts Mortality of Hemodialysis Patients [J].

Arsov, Stefan ;

Trajceska, Lada ;

van Oeveren, Wim ;

Smit, Andries J. ;

Dzekova, Pavlina ;

Stegmayr, Bernd ;

Sikole, Aleksandar ;

Rakhorst, Gerhard ;

Graaff, Reindert .

ARTIFICIAL ORGANS, 2013, 37 (07) :E114-E122

[2] Potential cardiovascular risk factors in chronic kidney disease:: AGEs, total homocysteine and metabolites, and the C-reactive protein [J].

Busch, M ;

Franke, S ;

Müller, A ;

Wolf, M ;

Gerth, J ;

Ott, U ;

Niwa, T ;

Stein, G .

KIDNEY INTERNATIONAL, 2004, 66 (01) :338-347

[3] Daily haemodialysis improves indices of protein glycation [J].

Floridi, A ;

Antolini, F ;

Galli, F ;

Fagugli, RM ;

Floridi, E ;

Buoncristiani, U .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2002, 17 (05) :871-878

[4] The role of advanced glycation end products in progression and complications of diabetes [J].

Goh, Su-Yen ;

Cooper, Mark E. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (04) :1143-1152

[5] Risk factors for chronic transplant dysfunction and cardiovascular disease are related to accumulation of advanced glycation end-products in renal transplant recipients [J].

Hartog, Jasper W. L. ;

de Vries, Aiko P. J. ;

Bakker, Stephan J. L. ;

Graaff, Reindert ;

van Son, Willem J. ;

van der Heide, Jaap J. Homan ;

Gans, Reinold O. B. ;

Wolffenbuttel, Bruce H. R. ;

de Jong, Paul E. ;

Smit, Andries J. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (08) :2263-2269

[6] Advanced glycated end-products (AGE) during haemodialysis treatment:: discrepant results with different methodologies reflecting the heterogeneity of AGE compounds [J].

Henle, T ;

Deppisch, R ;

Beck, W ;

Hergesell, O ;

Hänsch, GM ;

Ritz, E .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (08) :1968-1975

[7] Reference Values of Skin Autofluorescence [J].

Koetsier, M. ;

Lutgers, H. L. ;

de Jonge, C. ;

Links, T. P. ;

Smit, A. J. ;

Graaff, R. .

DIABETES TECHNOLOGY & THERAPEUTICS, 2010, 12 (05) :399-403

[8] Skin color independent assessment of aging using skin autofluorescence [J].

Koetsier, Marten ;

Nur, Erfan ;

Han Chunmao ;

Lutgers, Helen L. ;

Links, Thera P. ;

Smit, Andries J. ;

Rakhorst, Gerhard ;

Graaff, Reindert .

OPTICS EXPRESS, 2010, 18 (14) :14416-14429

[9] Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients [J].

Meerwaldt, R ;

Hartog, JWL ;

Graaff, R ;

Huisman, RJ ;

Links, TP ;

den Hollander, NC ;

Thorpe, SR ;

Baynes, JW ;

Navis, G ;

Gans, ROB ;

Smit, AJ .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (12) :3687-3693

[10] Simple non-invasive assessment of advanced glycation endproduct accumulation [J].

Meerwaldt, R ;

Graaff, R ;

Oomen, PHN ;

Links, TP ;

Jager, JJ ;

Alderson, NL ;

Thorpe, SR ;

Baynes, JW ;

Gans, ROB ;

Smit, AJ .

DIABETOLOGIA, 2004, 47 (07) :1324-1330

← 1 2 →