A highly efficient heterogeneous copper-catalyzed cascade reaction of 2-halobenzoic acids and amidines leading to quinazolinones

被引：24

作者：

He, Wen ^{[1
,2
]}

Zhao, Hong ^{[3
]}

Yao, Ruiya ^{[1
,2
]}

Cai, Mingzhong ^{[1
,2
]}

机构：

[1] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Peoples R China

[2] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China

[3] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 91期

基金：

中国国家自然科学基金;

关键词：

MESOPOROUS MOLECULAR-SIEVES; 3+2 HUISGEN CYCLOADDITION; COUPLING REACTIONS; C-N; NITROGEN-HETEROCYCLES; RECYCLABLE CATALYST; SUPPORTED CATALYST; PARALLEL SYNTHESIS; ALIPHATIC-AMINES; ROOM-TEMPERATURE;

D O I：

10.1039/c4ra09379h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The heterogeneous cascade reaction of 2-halobenzoic acids and amidines was achieved in DMF at 60 degrees C in the presence of 10 mol% of MCM-41-immobilized tridentate nitrogen copper(I) complex [MCM-41-3N-CuI] using Cs2CO3 as base, yielding a variety of quinazolinone derivatives in good to excellent yields. This heterogeneous copper catalyst can be easily prepared from commercially available and inexpensive reagents, and recovered by a simple filtration of the reaction solution and reused for at least 10 times without any decreases in activity.

引用

页码：50285 / 50294

页数：10

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