FOXP3 and scurfy: how it all began

被引：170

作者：

Ramsdell, Fred ^{[1
]}

Ziegler, Steven F. ^{[2
]}

机构：

[1] Novo Nordisk Inflammat Res Ctr, Seattle, WA 98109 USA

[2] Benaroya Res Inst, Seattle, WA 98101 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 05期

关键词：

REGULATORY T-CELLS; TRANSCRIPTION FACTOR FOXP3; X-LINKED SYNDROME; ROR-GAMMA-T; SF MOUSE; LYMPHORETICULAR DISEASE; GENE-EXPRESSION; C-REL; LINEAGE SPECIFICATION; AUTOIMMUNE-DISEASE;

D O I：

10.1038/nri3650

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been 65 years since the scurfy mutation arose spontaneously in mice at the Oak Ridge National Laboratory in the United States, and it is 13 years since the molecular cloning of the forkhead box P3 (FOXP3) gene was reported. In this Timeline article, we review the events that have occurred during and since this time. This is not meant as an exhaustive review of the biology of FOXP3 or of regulatory T cells, rather it is an attempt to highlight the landmark events that have demonstrated the importance of FOXP3 in immune function. These events have driven, and continue to drive, the extensive research effort to fully understand the role of regulatory T cells in the immune system.

引用

页码：343 / 349

页数：7

共 83 条

[1] Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production [J].

Allan, Sarah E. ;

Crome, Sarah Q. ;

Crellin, Natasha K. ;

Passerini, Laura ;

Steiner, Theodore S. ;

Bacchetta, Rosa ;

Roncarolo, Maria G. ;

Levings, Megan K. .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (04) :345-354

[2] The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs [J].

Allan, SE ;

Passerini, L ;

Bacchetta, R ;

Crellin, N ;

Dai, MY ;

Orban, PC ;

Ziegler, SF ;

Roncarolo, MG ;

Levings, MK .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) :3276-3284

[3] Defective regulatory and effector T cell functions in patients with FOXP3 mutations [J].

Bacchetta, Rosa ;

Passerini, Laura ;

Gambineri, Eleonora ;

Dai, Minyue ;

Allan, Sarah E. ;

Perroni, Lucia ;

Dagna-Bricarelli, Franca ;

Sartirana, Claudia ;

Matthes-Martins, Susanne ;

Lawitschka, Anita ;

Azzari, Chiara ;

Ziegler, Steven F. ;

Levings, Megan K. ;

Roncarolo, Maria Grazia .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (06) :1713-1722

[4]

Bandukwala HS, 2011, IMMUNITY, V34, P479, DOI 10.1016/j.immuni.2011.02.017

[5] DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells [J].

Baron, Udo ;

Floess, Stefan ;

Wieczorek, Georg ;

Baumann, Katrin ;

Gruetzkau, Andreas ;

Dong, Jun ;

Thiel, Andreas ;

Boeld, Tina J. ;

Hoffmann, Petra ;

Edinger, Matthias ;

Tuerbachova, Ivana ;

Hamann, Alf ;

Olek, Sven ;

Huehn, Jochen .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (09) :2378-2389

[6] The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].

Bennett, CL ;

Christie, J ;

Ramsdell, F ;

Brunkow, ME ;

Ferguson, PJ ;

Whitesell, L ;

Kelly, TE ;

Saulsbury, FT ;

Chance, PF ;

Ochs, HD .

NATURE GENETICS, 2001, 27 (01) :20-21

[7] Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells [J].

Bettelli, E ;

Dastrange, M ;

Oukka, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (14) :5138-5143

[8]

BLAIR PJ, 1994, J IMMUNOL, V153, P3764

[9] Natural versus adaptive regulatory T cells [J].

Bluestone, JA ;

Abbas, AK .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (03) :253-257

[10] Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse [J].

Brunkow, ME ;

Jeffery, EW ;

Hjerrild, KA ;

Paeper, B ;

Clark, LB ;

Yasayko, SA ;

Wilkinson, JE ;

Galas, D ;

Ziegler, SF ;

Ramsdell, F .

NATURE GENETICS, 2001, 27 (01) :68-73

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