Genetic diversity of HLA system in six populations from Jalisco, Mexico: Guadalajara city, Tlajomulco, Tlaquepaque, Tonala, Zapopan and rural Jalisco

被引：3

作者：

Bravo-Acevedo, Alicia ^{[1
]}

Escobedo-Ruiz, Araceli ^{[2
]}

Barquera, Rodrigo ^{[3
,4
]}

Clayton, Stephen ^{[4
]}

Eduardo Garcia-Arias, Victor ^{[5
]}

Arrieta-Bolanos, Esteban ^{[6
]}

Gone-Vazquez, Isis ^{[2
]}

Iraiz Hernandez-Zaragoza, Diana ^{[3
,7
]}

Paulina Arellano-Prado, Francia ^{[5
]}

Estefania Rodriguez-Lopez, Marla ^{[5
]}

de Jesus Sanchez-Fernandez, Maria Guadalupe ^{[8
]}

Sandoval-Sandoval, Mario J. ^{[9
]}

Gomez-Navarro, Benjamin ^{[10
]}

Zuniga, Joaquin ^{[11
,12
]}

Yunis, Edmond J. ^{[13
]}

Bekker-Mendez, Carolina ^{[14
]}

Granados, Julio ^{[15
]}

机构：

[1] Inst Mexicano Seguro Social IMSS, UMAE Hosp Gineco Obstet Luis Castelazo Ayala 4, Blood Bank, Mexico City, DF, Mexico

[2] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Hosp Especialidades, Histocompatibil Lab, Guadalajara, Jalisco, Mexico

[3] Escuela Nacl Antropol & Hist ENAH, Mol Genet Lab, Mexico City, DF, Mexico

[4] Max Planck Inst Sci Human Hist MPI SHH, Dept Archaeogenet, Jena, Germany

[5] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Pediat Hosp, Guadalajara, Jalisco, Mexico

[6] Univ Hosp Essen, Inst Expt Cellular Therapy, Essen, Germany

[7] Tecn Genet Aplicadas Clin TGAC, Immunogenet Unit, Mexico City, DF, Mexico

[8] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Dept Nephrol & Transplantat Unit, Guadalajara, Jalisco, Mexico

[9] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Cent Off Transplantat, Guadalajara, Jalisco, Mexico

[10] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Cent Off Nephrol, Guadalajara, Jalisco, Mexico

[11] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Immunobiol & Genet, Mexico City, DF, Mexico

[12] Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, DF, Mexico

[13] Dana Farber Canc Inst, Dept Canc Immunol & Virol, Boston, MA 02115 USA

[14] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Infectol Hosp, Immunol & Infectol Res Unit, Calzada Vallejo & Jacarandas S-N, Mexico City 02990, DF, Mexico

[15] Inst Nacl Ciencias Med & Nutr Salvador Zubiran IN, Dept Transplantat, Mexico City, DF, Mexico

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 09期

关键词：

HLA; Immunogenetics; Population genetics; Jalisco; Admixture; ALLELE FREQUENCIES; MESTIZOS; ADMIXTURE; DIFFERENTIATION; IMPACT;

D O I：

10.1016/j.humimm.2019.05.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2046 Mexicans from the state of Jalisco living in the city of Guadalajara (N = 1189), Tlajomulco (N = 30), Tlaquepaque (N = 39), Tonala (N = 35), Zapopan (N = 168) and rural communities (N = 585), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Jalisco include nine Native American most probable ancestry and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Jalisco are European (48.45 +/- 1.18% by ML; 41.66% of European haplotypes) and Native American (44.02 +/- 1.24% by ML; 39.86% of Native American haplotypes), while African genetic component is less apparent (7.53 +/- 0.30% by ML; 9.62% of African haplotypes).

引用

页码：502 / 505

页数：4

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